DMT-dC(ac) Phosphoramidite
Based on 1 publication(s) in Google Scholar
DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 154110-40-4
- Formula: C41H50N5O8P
- Molecular Weight:771.84
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DMT-dC(ac) Phosphoramidite
MoreAll DNA/RNA Synthesis Isoforms
More
Biological Activity
Chemical Information
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CAS No. 154110-40-4
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Appearance Solid
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Molecular Weight 771.84
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Formula C41H50N5O8P
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Color White to off-white
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SMILES
COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N4C=CC(NC(C)=O)=NC4=O)O3)C5=CC=CC=C5)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Discov Oncol
POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer. [Abstract]2024 Nov 9;15(1):633. PMID: 39520627
Solvent & Solubility
DMSO : 100 mg/mL (129.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2956 mL | 6.4780 mL | 12.9561 mL | 32.3901 mL |
| 5 mM | 0.2591 mL | 1.2956 mL | 2.5912 mL | 6.4780 mL | |
| 10 mM | 0.1296 mL | 0.6478 mL | 1.2956 mL | 3.2390 mL | |
| 15 mM | 0.0864 mL | 0.4319 mL | 0.8637 mL | 2.1593 mL | |
| 20 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL | 1.6195 mL | |
| 25 mM | 0.0518 mL | 0.2591 mL | 0.5182 mL | 1.2956 mL | |
| 30 mM | 0.0432 mL | 0.2159 mL | 0.4319 mL | 1.0797 mL | |
| 40 mM | 0.0324 mL | 0.1620 mL | 0.3239 mL | 0.8098 mL | |
| 50 mM | 0.0259 mL | 0.1296 mL | 0.2591 mL | 0.6478 mL | |
| 60 mM | 0.0216 mL | 0.1080 mL | 0.2159 mL | 0.5398 mL | |
| 80 mM | 0.0162 mL | 0.0810 mL | 0.1620 mL | 0.4049 mL | |
| 100 mM | 0.0130 mL | 0.0648 mL | 0.1296 mL | 0.3239 mL |
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