N-Acetyl-L-arginine (Synonyms: Ac-Arg-OH)

Name: N-Acetyl-L-arginine
Brand: MedChemExpress
SKU: HY-W014130
Rating: 4.5 (1 reviews)

Cat. No.: HY-W014130 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

For research use only. We do not sell to patients.

N-Acetyl-L-arginine Chemical Structure

CAS No. : 155-84-0

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10 mM * 1 mL in DMSO ready for reconstitution	USD 39	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 39	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of N-Acetyl-L-arginine:

N-Acetyl-L-arginine dihydrate Get quote

1 Publications Citing Use of MCE N-Acetyl-L-arginine

•Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.

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Description

N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

216.24

Formula

C₈H₁₆N₄O₃

CAS No.

155-84-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C)N[C@@H](C(O)=O)CCCNC(N)=N

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (231.22 mM; Need ultrasonic)

DMSO : 14.29 mg/mL (66.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6245 mL	23.1225 mL	46.2449 mL
5 mM	0.9249 mL	4.6245 mL	9.2490 mL
10 mM	0.4624 mL	2.3122 mL	4.6245 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.43 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.43 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.43 mg/mL (6.61 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 130 mg/mL (601.18 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (0 KB)

COA (244 KB) HNMR (255 KB)

Handling Instructions (2659 KB)

References

[1]. De Deyn PP, et al. Serum guanidino compound levels in uremic pediatric patients treated with hemodialysis or continuous cycle peritoneal dialysis. Correlations between nerve conduction velocities and altered guanidino compound concentrations. Nephron. 1995;69(4):411-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.6245 mL	23.1225 mL	46.2449 mL	115.6123 mL
	5 mM	0.9249 mL	4.6245 mL	9.2490 mL	23.1225 mL
	10 mM	0.4624 mL	2.3122 mL	4.6245 mL	11.5612 mL
	15 mM	0.3083 mL	1.5415 mL	3.0830 mL	7.7075 mL
	20 mM	0.2312 mL	1.1561 mL	2.3122 mL	5.7806 mL
	25 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6245 mL
	30 mM	0.1541 mL	0.7707 mL	1.5415 mL	3.8537 mL
	40 mM	0.1156 mL	0.5781 mL	1.1561 mL	2.8903 mL
	50 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	60 mM	0.0771 mL	0.3854 mL	0.7707 mL	1.9269 mL
H₂O	80 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
H₂O	100 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1561 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

N-Acetyl-L-arginine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-L-arginine155-84-0Ac-Arg-OHEndogenous MetaboliteInhibitorinhibitorinhibit

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N-Acetyl-L-arginine (Synonyms: Ac-Arg-OH)

Customer Review

Other Forms of N-Acetyl-L-arginine:

N-Acetyl-L-arginine Related Antibodies

1 Publications Citing Use of MCE N-Acetyl-L-arginine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

N-Acetyl-L-arginine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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