AC-45594
Based on 1 Customer Validation
AC-45594 (4-(Hexyloxy)phenol) is a UPR activator. AC-45594 induces endoplasmic reticulum stress, activates the unfolded protein response (UPR), and drives the transition from adaptive stress signaling to terminal stress signaling, ultimately leading to cell Apoptosis. AC-45594 activates Caspase-3, induces PARP cleavage, and increases the protein level of DR5. AC-45594 selectively inhibits the growth of Ewing sarcoma cells.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 18979-55-0
- Formula: C12H18O2
- Molecular Weight:194.27
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Storage:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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All Caspase Isoforms
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Biological Activity
|
Caspase 3 |
Caspase 8 |
Caspase-7 |
AC-45594 (72 h) selectively inhibits the growth of Ewing sarcoma cell lines COG-E-352, SK-ES-1, TC-32, SKNMC, TC-71 and TC-106 in a concentration-dependent manner, with EC50 values ranging from 45.0 ± 2.2 to 144.3 ± 13.0 nM[1].
AC-45594 (25-200 nM; 72 h) induces apoptosis in SK-ES-1 and TC-71 Ewing sarcoma cell lines, while reducing the cell populations in the S and G2/M phases[1].
AC-45594 (200 nM; 8-16 h) triggers sequential activation of the unfolded protein response and pro-apoptotic signaling in SK-ES-1 Ewing sarcoma cells, with early stress response changes observed at 8 h post-treatment, and extensive UPR activation and apoptosis initiation detected at 16 h post-treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ewing sarcoma cell lines (SK-ES-1, TC-71)
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Concentration:25, 50, 100 nM
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Incubation Time:72 h
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Result:Did not alter cell cycle distribution in SK-ES-1 or TC-71 cells at 50 nM (below EC50 values for both cell lines).
Significantly reduced the proportion of SK-ES-1 cells in S (12.97 ± 0.32% vs 21.83 ± 0.49% in control) and G2/M (20.27 ± 0.03% vs 22.57 ± 0.15% in control) phases, and increased apoptotic cells to 4.70 ± 0.12% at 100 nM.
Reduced the proportion of TC-71 cells in S (12.97 ± 0.32% vs 20.60 ± 0.90% in control) and G2/M (16.20 ± 0.38% vs 25.47 ± 0.27% in control) phases, and increased apoptotic cells to 20.23 ± 0.20% at 100 nM.
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Cell Line:Ewing sarcoma cell lines (SK-ES-1, TC-71)
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Concentration:100, 200, 300 nM (72 h); 200 nM (8, 16, 24, 48 h)
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Incubation Time:8, 16, 24, 48, 72 h
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Result:Activated caspase-3 and induced PARP cleavage in TC-71 and SK-ES-1 cells at 100 nM or higher.
Activated caspase-3, -7, and -8, induced PARP cleavage, and increased DR5 protein levels as early as 8 hours in both cell lines at 200 nM.
Chemical Information
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CAS No. 18979-55-0
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Appearance Solid
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Molecular Weight 194.27
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Formula C12H18O2
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Color Off-white to yellow
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SMILES
CCCCCCOC1=CC=C(O)C=C1
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Synonyms
4-(Hexyloxy)phenol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (268 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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