2. GPCR/G Protein
  3. GCGR
  4. [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist.

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Kundenspezifische Peptidsynthese

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Chemische Struktur

CAS. Nr. : 93965-89-0

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[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Related Antibodies

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Beschreibung

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist[1].

IC50 & Target

VIP[1]
In Vitro

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) selectively inhibits both VIP and GRF-stimulated adenylate cyclase activities in rat pancreatic plasma membranes[1].
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) (0.1 pM-10 nM; 3 d) induces a dose-dependent cell proliferation increase in C6 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Related Antibodies

Cell Proliferation Assay[2]

Cell Line: C6 rat glioblastoma cells
Concentration: 0.1 pM-10 nM
Incubation Time: 3 days
Result: Induced a dose-dependent cell proliferation increase.
Molekulargewicht

3476.01

Formel

C157H252N44O43S
CAS. Nr.
Sequence

Ac-Tyr-{d-Phe}-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Sequence Shortening

Ac-Y-{d-Phe}-DAIFTNSYRKVLGQLSARKLLQDIMSR-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Reinheit & Dokumentation
Verweise
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[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)93965-89-0GCGRGlucagon ReceptorGRFgrowth hormone releasing factorVIPvasoactive intestinal peptideInhibitorinhibitorinhibit

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