1. Epigenetics
  2. Epigenetic Reader Domain
    Histone Acetyltransferase
  3. CBP/p300-IN-12

CBP/p300-IN-12 

Cat. No.: HY-132197
Handling Instructions

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450.

For research use only. We do not sell to patients.

CBP/p300-IN-12 Chemical Structure

CBP/p300-IN-12 Chemical Structure

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Description

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450[1].

IC50 & Target

IC50: 166 nM (p300 HAT domain)[1]

In Vitro

CBP/p300-IN-12 (Compound 2) shows antiproliferative effect against androgen receptor (AR)-positive LnCaP-FGC cells (EC50 of 87 nM), while displaying significantly less activity in the AR-negative cell line DU-145 (EC50 of 1.37 μM).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

667.61

Formula

C₃₃H₂₉F₄N₅O₆

SMILES

C=CC(NC1=CC=CC(NC(NC2=CC3=C([[email protected]]4(OC(N(CC(N(CC5=CC=C(F)C=C5)[[email protected]@H](C)C(F)(F)F)=O)C4=O)=O)CC3)C=C2)=O)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CBP/p300-IN-12Epigenetic Reader DomainHistone AcetyltransferaseHATsHATp300CBPacrylamideC1450H3K27AcantiproliferativeInhibitorinhibitorinhibit

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Product Name:
CBP/p300-IN-12
Cat. No.:
HY-132197
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