2. Ac-DEVD-CMK

Ac-DEVD-CMK  (Synonyms: Caspase-3 Inhibitor III)

Cat. No.: HY-P0034
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Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis.

For research use only. We do not sell to patients.

Ac-DEVD-CMK Chemical Structure

Ac-DEVD-CMK Chemical Structure

CAS No. : 285570-60-7

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Ac-DEVD-CMK Related Antibodies

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Description

Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].

In Vitro

Ac-DEVD-CMK (100 μM; 24 h) inhibits IDB-induced apoptosis[3].
Ac-DEVD-CMK inhibits (10 μM; 36 h) inhibits citrate (10 mM)-induced p21 cleavage and G2/M accumulation in human pharyngeal squamous carcinoma FaDu and Detroit 562 cell lines[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-DEVD-CMK Related Antibodies

Apoptosis Analysis[3]

Cell Line: Jurkat cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Inhibited ingenol IDB (10 μM)-induced apoptosis.
In Vivo

Ac-DEVD-CMK (Caspase-3 Inhibitor III; 25 mg/kg; IP; single dose; 3 hours post-APAP) significantly attenuates Acetaminophen (APAP; HY-66005)-induced liver injury (AILI)[5].
Ac-DEVD-CMK (25 mg/kg; ip; single dose) significantly attenuates APAP-induced liver injury (AILI) in susceptible Sdc1−/− mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old females and males Sdc1-/- mice[4]
Dosage: 25 mg/kg
Administration: IP; single dose; 3 hours post-APAP
Result: Significantly attenuated APAP (ip; 500 or 625 mg/kg)-induced liver injury (AILI), indicating that inhibition of GSK-3β or caspase-3 activity mitigates liver damage.
Molecular Weight

550.94

Formula

C21H31ClN4O11
CAS No.
SMILES

ClCC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-DEVD-CMK285570-60-7Caspase-3 Inhibitor IIIInhibitorinhibitorinhibit

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