Ac-RYYRWK-NH2 TFA
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for μ-, κ- or δ-opioid receptors.
For research use only. We do not sell to patients.
- CAS No.: 408305-09-9
- Formula: C51H70F3N15O11
- Molecular Weight:1126.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NOP Receptor/ORL1 |
[3H]ac-RYYRWK-NH2 binding to rat cortical membranes revealed a single high affinity site for [3H]ac-RYYRWK-NH2 (Kd=0.071 nM)[1]. Naloxone benzoylhydrazone displaced [3H]acRYYRWK-NH2 binding to rat cortical membranes (Ki=104 nM) and human ORL1 (Ki=136 nM) as well as [125I]Tyr14-NC-OH to ORL1 (Ki=37 nM) has no affinity for μ-, κ- or δ-opioid receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 408305-09-9
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Molecular Weight 1126.19
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Formula C51H70F3N15O11
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Sequence Shortening
Ac-RYYRWK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. [Content Brief]
[2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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