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Results for "

MG degrader1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 17β-HSD (1) AAK1 (1) Acetyl-CoA Carboxylase (1) ACSL Family (1) ADC Linker (1) ADC Payload (1) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (8) Aldose Reductase (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (4) Angiotensin-converting Enzyme (ACE) (1) Annexin A (1) Antibiotic (1) AP-1 (1) Apoptosis (48) Aquaporin (1) ATM/ATR (3) ATTECs (4) Aurora Kinase (5) AUTACs (2) Autophagy (12) Bacterial (1) Bcl-2 Family (8) BCL6 (2) Bcr-Abl (2) Biochemical Assay Reagents (5) Btk (6) c-Met/HGFR (2) c-Myc (9) CaMK (1) Cannabinoid Receptor (1) Carbonic Anhydrase (1) Casein Kinase (3) Caspase (7) CCR (2) CDK (37) Checkpoint Kinase (Chk) (3) CRM1 (3) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (1) DAPK (2) Deubiquitinase (3) Dihydrofolate reductase (DHFR) (1) Discoidin Domain Receptor (2) DNA Methyltransferase (2) DNA/RNA Synthesis (7) Drug Derivative (5) Drug Intermediate (6) Drug Isomer (2) Drug Metabolite (1) DYRK (2) E1/E2/E3 Enzyme (10) E3 Ligase Ligand-Linker Conjugates (85) Early 2 Factor (E2F) (1) EGFR (3) Endogenous Metabolite (5) Enterovirus (1) Environmental Pollutants (5) Epigenetic Reader Domain (31) Epoxide Hydrolase (1) ERK (8) Estrogen Receptor/ERR (10) Eukaryotic Initiation Factor (eIF) (1) FAK (3) Fat Mass and Obesity-associated Protein (FTO) (1) Ferroptosis (4) FGFR (4) FKBP (6) FLT3 (8) G Protein-coupled Receptor Kinase (GRK) (1) GLP Receptor (1) Glutaminase (1) Glutathione Peroxidase (3) Glycosidase (5) GSK-3 (3) HBV (3) HDAC (9) Herbicide (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (5) Histone Demethylase (2) Histone Methyltransferase (17) HIV (4) HMG-CoA Reductase (HMGCR) (1) HSP (8) Hsp-targeting Chimeras (3) Huntingtin (2) HyT (5) IAP (6) IKK (2) IKZF Family (12) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (2) Insecticide (1) Interleukin Related (7) IRAK (5) Isotope-Labeled Compounds (3) Itk (1) JAK (8) JNK (3) Keap1-Nrf2 (1) Kinesin (1) Kisspeptin Receptor (1) LAG-3 (1) Ligands for E3 Ligase (28) Ligands for Target Protein for PROTAC (83) LRRK2 (1) LYTACs (2) MAGL (2) MALT1 (2) MAP3K (1) MAP4K (1) MDM-2/p53 (2) MEK (4) METTL3 (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Mixed Lineage Kinase (1) MMP (1) MNK (2) Molecular Glues (26) Mps1 (3) NAMPT (2) Necroptosis (2) NEKs (1) NF-κB (4) NOD-like Receptor (NLR) (3) Nuclear Hormone Receptor 4A/NR4A (1) Oxysterol-binding Protein-related Protein (ORP) (3) p62 (1) Parasite (2) PARP (7) PCSK9 (2) PD-1/PD-L1 (4) PDI (1) PERK (1) Phosphatase (4) Phosphodiesterase (PDE) (4) PI3K (6) PIN1 (5) PNPLA3 (2) PROTAC Linkers (43) PROTAC-Linker Conjugates for PAC (3) PROTACs (245) Proteasome (1) Raf (2) RAR/RXR (1) Ras (15) Reactive Oxygen Species (ROS) (4) Reference Standards (7) RET (3) RIP kinase (3) ROR (2) SARS-CoV (2) SGK (2) SHP2 (2) Sirtuin (2) SNIPERs (5) SOS1 (5) SphK (1) Src (2) STAT (12) STING (2) Survivin (4) SWI/SNF Complex (1) TAM Receptor (1) Target Protein Ligand-Linker Conjugates (32) Tau Protein (2) TNF Receptor (2) Toll-like Receptor (TLR) (1) Transferrin Receptor (2) Trk Receptor (2) TRP Channel (1) VEGFR (1) WDR5 (4) Wee1 (2) Wnt (2) YAP (8) YTHDF (1) α-synuclein (1) β-catenin (2)
By Research Areas:	Cancer (519) Cardiovascular Disease (4) Endocrinology (1) Infection (22) Inflammation/Immunology (39) Metabolic Disease (17) Neurological Disease (21)
Click Chemistry:	DBCO (1) PROTAC Synthesis (9) Azide (8) Alkynes (7)

656

Inhibitors & Agonists

Fluorescent Dyes

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163897

PROTAC NCOA4 degrader-1	PROTACs Ferroptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology
PROTAC NCOA4 degrader-1 is a VHL-based PROTAC NCOA4 degrader. PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces Fe ²⁺ elevation, ROS production, MDA content and PTGS2 mRNA expression. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl₄-induced acute liver injury model. PROTAC NCOA4 degrader-1 can be used for the researches of inflammation and immunology. (Pink: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)) .

HY-176857

PROTAC STAT6 degrader-1	PROTACs STAT	Inflammation/Immunology Cancer
PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC₅₀ <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC₅₀ of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC) .

HY-168016

PROTAC YAP degrader-1	PROTACs YAP	Cancer
PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC₅₀=8.2 μM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma .

HY-163638

BRD4 degrader-1	Epigenetic Reader Domain Molecular Glues E1/E2/E3 Enzyme	Cancer
BRD4 degrader-1 (Compound mL 1-50) is a relatively selective, monovalent and covalent BRD4 Molecular glue degrader. BRD4 degrader-1 induces degradation of both long and short isoforms of BRD4 by targeting DCAF16 (an E3 ligase). BRD4 degrader-1 can be used in breast cancer research .

HY-176528

PROTAC ERK5 degrader-1	ERK PROTACs	Cancer
PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia .

HY-158342

PROTAC TEAD degrader-1	PROTACs YAP	Cancer
PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer .

HY-148691

PROTAC PTPN2 degrader-1	Phosphatase PROTACs	Metabolic Disease Cancer
PROTAC PTPN2 degrader-1 (compound example 77) is a potent PTPN2 degrader. PROTAC PTPN2 degrader-1 has the potential for the research of cancer or metabolic disease .

HY-173320

HEMTAC WEE1 degrader-1	Hsp-targeting Chimeras Wee1 HSP	Cancer
HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC₅₀: 16.76 nM). HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker) .

HY-158142

PROTAC TYK2 degrader-1	PROTACs JAK STAT	Inflammation/Immunology Cancer
PROTAC TYK2 degrader-1 is a TYK2 PROTAC degrader with a D_max ≥ 60%. PROTAC TYK2 degrader-1 reduces the phosphorylation levels of IFNα-induced STAT1 (Tyr701) and STAT3 (Tyr705) in immune cells. PROTAC TYK2 degrader-1 can be used in research on cancer, inflammatory diseases, etc.

HY-158045

PROTAC PARP1 degrader-1	PROTACs PARP	Cancer
PROTAC PARP1 degrader-1 is a PARP1 PROTAC degrader with a DC₅₀ value of 252.5 nM. PROTAC PARP1 degrader-1, combined with Daunorubicin (HY-13062A), induces the accumulation of cytoplasmic DNA fragments, activates the cGAS/STING innate immune pathway, and remodels the tumor microenvironment. PROTAC PARP1 degrader-1 can be used in research related to breast cancer .

HY-129523

PROTAC K-Ras Degrader-1 2 Publications Verification	PROTACs Ras	Cancer
PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells .

HY-153864

PROTAC MEK1 Degrader-1	PROTACs MEK ERK	Cancer
PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC₅₀ value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells .

HY-161108

PROTAC Chk1 degrader-1	PROTACs Checkpoint Kinase (Chk)	Cancer
PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .

HY-158345

PROTAC ATM degrader-1	PROTACs ATM/ATR DNA/RNA Synthesis Apoptosis	Cancer
PROTAC ATM degrader-1 is a ATM PROTAC degrader with a K_D value of 1.17 nM. PROTAC ATM degrader-1 triggers DNA damage response, cell cycle arrest, and apoptosis in cancer cells via the ubiquitin-proteasome-dependent degradation pathway. PROTAC ATM degrader-1 can be used for research on colorectal cancer .

HY-153415

PROTAC BCR-ABL Degrader-1	PROTACs Bcr-Abl	Cancer
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. PROTAC BCR-ABL Degrader-1 induces Bcr-Abl degradation in a ubiquitinproteasom-dependent manner. PROTAC BCR-ABL Degrader-1 exhibits antiproliferative activity against K562 cells, and has the potential to study cancer .

HY-142662A

*PROTAC IRAK3 degrade-1* formic**	PROTACs IRAK	Others
PROTAC IRAK3 degrader-1 formic is a potent and selective IRAK3 degrader with a DC₅₀ of 0.002 μM. PROTAC IRAK3 degrader-1 formic induces proteasome-dependent degradation of IRAK3 via ternary complex formation with IRAK3 and CRBN. PROTAC IRAK3 degrader-1 formic can be used for cancer research .

HY-163372

PROTAC HPK1 Degrader-1	PROTACs MAP4K	Cancer
PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC₅₀ value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC₅₀ value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling .

HY-161101

MG degrader 1	PROTACs IKZF Family	Cancer
MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC₅₀ value of 1.385 nM in MM.1S cells .

HY-168530

PDL1 degrader-1	PD-1/PD-L1	Cancer
PDL1 degrader-1 (compound PMT-O9-1A) is a potent PD-L1 degrader. PDL1 degrader-1 decreases the protein expression of PD-L1. PDL1 degrader-1 shows cytotoxicity. PDL1 degrader-1 shows anticancer activity .

HY-174428

PROTAC JAK2 degrader-1	PROTACs JAK STAT Apoptosis	Cancer
PROTAC JAK2 degrader-1 is a JAK2 PROTAC degrader, with a DC₅₀ of 27.35 nM. PROTAC JAK2 degrader-1 induces JAK2 degradation via the ubiquitin-proteasome pathway. PROTAC JAK2 degrader-1 inhibits the JAK2-STAT signaling pathway. PROTAC JAK2 degrader-1 induces G₂/M phase arrest and apoptosis in cancer cells. PROTAC JAK2 degrader-1 exhibits antiproliferative activity against cancer cells. PROTAC JAK2 degrader-1 inhibits recombinant human erythropoietin (rhEPO)-mediated polycythemia and splenomegaly in mice. PROTAC JAK2 degrader-1 can be used for research on myeloproliferative neoplasms, including polycythemia vera .

HY-156152A

*CARM1 degrader-1* hydrochloride**	PROTACs Histone Methyltransferase	Cancer
CARM1 degrader-1 hydrochloride is a CARM1 PROTAC degrader (DC₅₀ = 8.1 nM) with high selectivity over other protein arginine methyltransferases. CARM1 degrader-1 hydrochloride degrades CARM1 in a VHL- and proteasome-dependent manner. CARM1 degrader-1 hydrochloride downregulates the methylation level of CARM1 substrates in cell-based assays. CARM1 degrader-1 hydrochloride inhibits cancer cell migration in cell-based assays. CARM1 degrader-1 hydrochloride can be used in breast cancer research .

HY-168135

PROTAC c-Met degrader-1	PROTACs c-Met/HGFR	Cancer
PROTAC c-Met degrader-1 is a selective and orally active c-Met PROTAC degrader with a DC₅₀ of 6.21 nM against c-Met. PROTAC c-Met degrader-1 induces CRBN-dependent ubiquitination and proteasomal degradation of c-Met. PROTAC c-Met degrader-1 induces G0/G1 phase arrest in c-Met-dependent cancer cells. PROTAC c-Met degrader-1 kills c-Met-dependent cancer cells. PROTAC c-Met degrader-1 inhibits tumor growth in animal models. PROTAC c-Met degrader-1 can be used for the research of gastric cancer .

HY-145159

SHP2 protein degrader-1	SHP2 PROTACs Phosphatase Apoptosis	Cancer
SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases .

HY-176184

PROTAC DDR1 degrader-1	PROTACs Discoidin Domain Receptor MMP	Cancer
PROTAC DDR1 degrader-1 is a potent and selective DDR1-targeting PROTAC degrader. PROTAC DDR1 degrader-1 selectively induces full-length DDR1 degradation via the ubiquitin proteasome system, blocking downstream signaling pathways. PROTAC DDR1 degrader-1 inhibits tumor cell migration and invasion. PROTAC DDR1 degrader-1 exhibits anti-tumor activity in mice. PROTAC DDR1 degrader-1 can be used for the research of DDR1-driven cancers .

HY-155552

GSPT1 degrader-1	Apoptosis CDK Caspase	Cancer
GSPT1 degrader-1 is a highly selective degrader targeting GSPT1. GSPT1 degrader-1 induces degradation via the ubiquitin-proteasome system. GSPT1 degrader-1 induces G₀/G₁ phase arrest, apoptosis (apoptosis) and inhibits proliferation in leukemia cells. GSPT1 degrader-1 reduces the levels of CDK6 and Cyclin B1, while increases the levels of activated caspase-3 and caspase-9 in leukemia cells. GSPT1 degrader-1 can be used in leukemia research .

HY-147108

Mitochondria degrader-1	Mitochondrial Metabolism	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Mitochondria degrader-1 (example 5) is a potent mitochondria degrader. Mitochondria degrader-1 induces the degradation of the injured mitochondria by the autophagy mechanism. Mitochondria degrader-1 can be used for the research of neurodegenerative disease, cancer, inflammatory disease, age-related disease, metabolic disease, mitochondrial disease or Down's disease .

HY-145737A

*PROTAC SOS1 degrader-1* TFA**	Ras PROTACs SOS1	Cancer
PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC₅₀ of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .

HY-112098

PROTAC ERα Degrader-1 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.

HY-163295

BTK degrader-1	ADC Payload Btk	Cancer
BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect .

HY-160115

TDP-43 degrader-1	DNA/RNA Synthesis	Neurological Disease
TDP-43 degrader-1 (Compound example 7) is a TDP-43 degrader. TDP-43 degrader-1 reduces the aggregation of TDP-43-positive HuR stress granules in cells and promotes the relocalization of abnormally distributed TDP-43 in the cytoplasm to the nucleus. TDP-43 degrader-1 can be used in the study of amyotrophic lateral sclerosis and Alzheimer's disease .

HY-158985A

*Amino-PEG3-2G degrader-1* hydrochloride**	Autophagy AUTACs	Cancer
Amino-PEG3-2G degrader-1 hydrochloride is the hydrochloride salt form of Amino-PEG3-2G degrader-1 (HY-158985). Amino-PEG3-2G degrader-1 hydrochloride is a conjugate of a PEG Linker and a pyrazole-linked FBnG tag for ubiquitin-proteasome system (UPS) induction. Amino-PEG3-2G degrader-1 hydrochloride can be used to synthesize autophagy-targeting chimeras (AUTACs) .

HY-142662

PROTAC IRAK3 degrader-1	PROTACs IRAK	Cancer
PROTAC IRAK3 degrader-1 is a potent and selective IRAK3 degrader with a DC₅₀ of 0.002 μM. PROTAC IRAK3 degrader-1 induces proteasome-dependent degradation of IRAK3 via ternary complex formation with IRAK3 and CRBN. PROTAC IRAK3 degrader-1 can be used for cancer research .

HY-160532

CK1α degrader-1 1 Publications Verification	Casein Kinase	Cancer
CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC₅₀ of 0.105 μM. CK1α degrader-1 can be used for the research of cancer .

HY-157216

HDAC1 Degrader-1	HDAC	Cancer
HDAC1 Degrader-1 (compound 1a) is an HDAC1 degrader with anticancer activity. HDAC1 Degrader-1 significantly reduces HDAC1 levels in MM.1S multiple myeloma cells .

HY-168037

PROTAC PIN1 degrader-1	PROTACs PIN1	Cancer
PROTAC PIN1 degrader-1 is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer .

HY-133696

tert-Butyl 8-hydroxyoctanoate	PROTAC Linkers	Cancer
Tert-Butyl 8-hydroxyoctanoate is a PROTAC linker that can be used for the synthesis of PROTACs, such as PROTAC CDK Degrader-1 (HY-133617). PROTAC CDK Degrader-1 is a potent CDK PROTAC degrader with anti-tumor activity .

HY-163641

AR Degrader-1	Molecular Glues Androgen Receptor E1/E2/E3 Enzyme	Cancer
AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells .

HY-156152

CARM1 degrader-1	PROTACs Histone Methyltransferase	Cancer
CARM1 degrader-1 is a CARM1 PROTAC degrader (DC₅₀ = 8.1 nM) with high selectivity over other protein arginine methyltransferases. CARM1 degrader-1 degrades CARM1 in a VHL- and proteasome-dependent manner. CARM1 degrader-1 downregulates the methylation level of CARM1 substrates in cell-based assays. CARM1 degrader-1 inhibits cancer cell migration in cell-based assays. CARM1 degrader-1 can be used for the research of breast cancer .

HY-145737

PROTAC SOS1 degrader-1	PROTACs SOS1 Ras	Cancer
PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader with an DC₅₀ of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .

HY-175975

PROTAC Akt3 Degrader-1	PROTACs Akt	Cancer
PROTAC Akt3 Degrader-1 is a highly efficient and selective PROTAC degrader targeting Akt3. PROTAC Akt3 Degrader-1 shows weak antiproliferative activity in 36 cell lines. PROTAC Akt3 Degrader-1 can be used for the study of Triple-negative breast cancer and melanoma .

HY-147048

STAT3 degrader-1	STAT	Cancer
STAT3 degrader-1 (compound 295) is a potent STAT3 degrader. STAT3 degrader-1 can be used for researching anticancer . STAT3 degrader-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

HY-144657A

*(4S)-PROTAC SOS1 degrader-1* diTFA**	PROTACs Ras	Cancer
(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo .

HY-162014

WDR5 degrader-1	PROTACs WDR5	Cancer
WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1 .

HY-128838

PROTAC ERRα Degrader-1	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader .

HY-164895

PIN1 degrader-1	PIN1	Cancer
PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC₅₀ of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research .

HY-176526

*BTK degrader-1* intermediate**	Drug Intermediate Btk	Cancer
BTK degrader-1 intermediate (compound 5) is an intermediate for the synthesis of BTK degrader-1 (HY-163295). BTK degrader-1 can be used as an ADC toxin to synthesize antibody-drug conjugate (ADC) .

HY-170601

PROTAC JNK1 Degrader-1	PROTACs JNK	Inflammation/Immunology
PROTAC JNK1 Degrader-1 is a JNK1 PROTAC degrader with a DC₅₀ of 10 nM. PROTAC JNK1 Degrader-1 reduces the level of fibronectin. PROTAC JNK1 Degrader-1 can be used for the research of pulmonary fibrosis .

HY-177948

GRK2 degrader-1	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research .

HY-177744

GSPT2 degrader-1	Molecular Glues	Cancer
GSPT2 degrader-1 (compound 619) is a selective molecular glue GSPT2 degrader targeting GSPT2. GSPT2 degrader-1 contains Thalidomide (HY-14658) and the linker of MDEG-541 (HY-150259). GSPT2 degrader-1 induces the degradation, but not GSPT1 or myelocytomatosis oncogene (MYC). GSPT2 degrader-1 can be used for research of gastrointestinal cancer .

Cat. No.	Product Name	Type

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

HY-D2259

PFI-7	Fluorescent Dyes
PFI-7 is a probe, which binds to human GID4 (K_D is 79 nM), and antagonizes the binding of Pro/N-degrons. PFI-7 can be utilized in C-terminal to LisH (CTLH) complex research and development of targeted protein degradation .

Cat. No.	Product Name	Type

HY-W110929

Acid blue 1 Xylene blue; C.I. Acid blue 1	Biochemical Assay Reagents
Acid blue 1 (Xylene blue) is an anionic triarylmethane dye and substrate for photocatalytic degradation .

HY-W749852

Xanthine sodium, 98%	Biochemical Assay Reagents
Xanthine sodium, 98%, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, 98% also acts as an intermediate product on the pathway of purine degradation .

HY-NP200

Keratin azure	Biochemical Assay Reagents
Keratin azure can be used to monitor the degradation of (β)-keratin. Keratin azure can be used as a substrate in keratin assays to assess keratinase degradation .

HY-W749852A

Xanthine sodium, for cell culture	Biochemical Assay Reagents
Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation .

HY-NP0221

Rabbit Transferrin	Biochemical Assay Reagents
Rabbit Transferrin is the major iron-containing protein in plasma, responsible for transporting iron absorbed from the digestive tract and iron released by erythrocyte degradation .

Cat. No.	Product Name	Target	Research Area

HY-P2191

KISS1-305	Kisspeptin Receptor	Endocrinology
KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation .

HY-169235

DHHC3 ligand 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-P3171

Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W017389

Xanthine Maximum Cited Publications 8 Publications Verification	Structural Classification Natural Products Classification of Application Fields Endocrine diseases Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Microorganisms Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Source Classification Theaceae	Environmental Pollutants Endogenous Metabolite
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .

HY-N6769

Radicicol 4 Publications Verification Monorden	Antifungal Classification of Application Fields Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields Source Classification	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-W013021

Norbornene	Structural Classification Natural Products Mangifera pajang Kosterm. Plants Anacardiaceae Source Classification	Ligands for E3 Ligase
Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895) .

HY-113136

1-Methylguanosine 3 Publications Verification N1-Methylguanosine	Infection Natural Products Other disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite
1-Methylguanosine (N1-Methylguanosine) is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker .

HY-W017389R

Xanthine (Standard)	Structural Classification Natural Products Microorganisms Disease markers Endocrine diseases Nervous System Disorder Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Source Classification Theaceae	Reference Standards Endogenous Metabolite
Xanthine (Standard) is the analytical standard of Xanthine. This product is intended for research and analytical applications. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation . In Vitro: A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.

HY-113136R

1-Methylguanosine (Standard) N1-Methylguanosine (Standard)	Infection Structural Classification Natural Products Other disease Disease markers Endogenous metabolite Cancer Source Classification	Endogenous Metabolite Reference Standards
1-Methylguanosine (Standard) is the analytical standard of 1-Methylguanosine. This product is intended for research and analytical applications. 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker .

HY-N8180

Silyamandin	Flavonols Classification of Application Fields Lignans Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Flavonoids Glycine soya Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields Source Classification	Others
Silyamandin is a flavonolignan compound. Silydianin can form Silyamandin through oxidative degradation .

HY-W777618

Cinerin II (+)-Cinerin II	Structural Classification Natural Products Plants Compositae Phaseolus lunatus Billb. ex Beurl. Source Classification	Others
Cinerin II ((+)-Cinerin II) is a pyrethrin ester found in Chrysanthemum cinerariifolium. Cinerin II is a safe pesticide with rapid degradation .

HY-W777613

Jasmolin I (-)-Jasmolin I	Structural Classification Natural Products Plants Compositae Phaseolus lunatus Billb. ex Beurl. Source Classification	Others
Jasmolin I ((-)-Jasmolin I) is a pyrethrin ester found in Chrysanthemum cinerariifolium. Jasmolin I is a safe pesticide with rapid degradation .

Cat. No.	Product Name	Chemical Structure

HY-W017389S

Xanthine-13C,15N2
Xanthine- ¹³C, ¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .

HY-W142446S

2,6-Dichlorobenzamide-3,4,5-d3
2,6-Dichlorobenzamide-3,4,5-d₃ is the deuterium labeled 2,6-Dichlorobenzamide (HY-W142446). 2,6-Dichlorobenzamide is a herbicide degradation product that is relatively difficult to degrade .

HY-113136S

1-Methylguanosine-d3
1-Methylguanosine-d₃ (N1-Methylguanosine-d₃) is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker .

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .

Cat. No.	Product Name		Classification

HY-148476

Tri-GalNAc-DBCO		DBCO
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .

HY-147943

PROTAC BTK Degrader-1		PROTAC Synthesis
PROTAC BTK Degrader-1 is a potent, selective and orally active PROTAC BTK degrader with an IC₅₀ value of 34.51 nM and 64.56 nM for BTK WT and BTK-481S, respectively. PROTAC BTK Degrader-1 effectively reduces BTK protein levels and suppresses tumor growth . PROTAC BTK Degrader-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152263

*HEMTAC CDK4/6 degrader* 1**		PROTAC Synthesis
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K_d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in research of cancer . HEMTAC CDK4/6 degrader 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133138

Pomalidomide-PEG1-azide		Azide PROTAC Synthesis
Pomalidomide-PEG1-azide is an E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-PEG1-azide can be used to synthesis PROTAC BRD4 Degrader-1 (HY-133131) . PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.

HY-143904

PROTAC TTK degrader-1		PROTAC Synthesis
PROTAC TTK degrader-1 is a potent TTK (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-130652

Pomalidomide 4'-PEG3-azide		PROTAC Synthesis Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient *PARP1*?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-176795

SHP2 ligand-3		Alkynes
SHP2 ligand-3 is a PROTAC target protein ligand that can be used to synthesize SHP2 protein degrader-1 (HY-145159) .

HY-W457949

Pomalidomide 4'-alkylC4-azide		Azide
Pomalidomide 4'-alkylC4-azide (Compound 2) is an azide compound containing a MIDI group and is one of the compounds used to construct a library of MIDI azide compounds. Pomalidomide 4'-alkylC4-azide is an E3 ligase ligand and linker conjugate (E3 Ligase Ligand-Linker Conjugate). Pomalidomide 4'-alkylC4-azide can be used to develop research on PROTAC degraders .

HY-178035

OSBP ligand-1		Alkynes
OSBP ligand-1 (Compound 2) is an Oxysterol-binding protein (OSBP) inhibitor. OSBP ligand-1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .

HY-178118

*PROTAC PDIA1 degrader* 1**		Alkynes
PROTAC PDIA1 degrader 1 (Compound H4) is a PDIA1 PROTAC degrader with a DC₅₀ of 29.71 μM. PROTAC PDIA1 degrader 1 has potent anticancer activity and significantly inhibits cancer cell proliferation . Pink: PDIA1 ligand (HY-100433); Blue: CRBN ligase ligand (HY-10984); Black: linker (HY-W015088)

HY-175827

MK-5108-NH-PEG2-alkyne		Alkynes
MK-5108-NH-PEG2-alkyne is a Aurora kinase A (AURKA) inhibitor. MK-5108-NH-PEG2-alkyne can be used for synthesis of PROTAC AURKA degrader 1 (HY-175830) .

HY-159777

JQ-1-PEG5-Alkyne		Alkynes
CPI-203-PEG5-Alkyne is a conjugate of target protein ligase and linker. CPI-203-PEG5-Alkyne can be used for synthesis of PROTAC BRD4-DCAF1 degrader-1 (HY-169151) .

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-130984

Azido-PEG1-CH2COO-Cl		PROTAC Synthesis Azide
Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131) . Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-181534

PROTAC TEAD1/IAP degrader-1		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective TEAD1 and cIAP1 PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the TEAD-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-181536

TEAD ligand 2		PROTAC Synthesis
TEAD ligand 2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC TEAD1/IAP degrader-1 (HY-181534). PROTAC TEAD1/IAP degrader-1 is a potent TEAD1/IAP PROTAC degrader with anti-cancer activity .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-180901

BRD3 ligand-1		Alkynes
BRD3 ligand-1 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC BRD3 degrader-1 (HY-180889) .

HY-180902

Pomalidomide-C11-azide		Azide
Pomalidomide-C11-azide is a synthetic E3 ligase ligand-linker conjugate, which can be used for the synthesis of PROTAC BRD3 degrader-1 (HY-180889) .

HY-182978

Pomalidomide-C3-O-C4-O-C3-NH2		PROTAC Synthesis
Pomalidomide-C3-O-C4-O-C3-NH2 is an E3 ligase ligand-linker conjugate that contains Pomalidomide (HY-10984). Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTACs targeting glycogen synthase kinase 3β (GSK-3β), such as PROTAC GSK-3β Degrader-1 (HY-149845) .

HY-178067

Phthalimidinoglutarimide-5-piperazine-COC2-alkynes		Alkynes
Phthalimidinoglutarimide-5-piperazine-COC2-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BCL-xL/BCL-w Degrader 1 (HY-178066). PROTAC BCL-xL/BCL-w Degrader 1 is a potent BCL-xL/BCL-w PROTAC degrader with anti-cancer activity .

HY-179603

(S,R,S)-AHPC-PEG3-azide		Azide
E3 Ligase Ligand-linker Conjugate 220 is an E3 ligase ligand-linker conjugate, can be used for synthesis of PROTAC 11β-HSD1 Degrader 1 (HY-179602) .

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