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Cat. No.: HY-180180

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trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid

trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid is a PROTAC linker. trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid can be used to synthesize PROTAC BLIMP-1 degrader-1 (HY-180177).

For research use only. We do not sell to patients.

Formula: C₁₄H₁₉NO₃
Molecular Weight:249.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PROTAC Linkers Isoforms :

Chemical Information

Molecular Weight 249.31
Formula C₁₄H₁₉NO₃
SMILES

OC(C1=NC(C)=C([C@H]2CC[C@@H](CC2)CO)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Simmons BJ, et al. Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders. J Med Chem. 2025 Dec 11;68(23):25385-25402. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid

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Biological Activity
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trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid

All PROTAC Linkers Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid Related Classifications

HY-180180 Related Classifications

Bioz

Keywords

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