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Cat. No.: HY-180177

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PROTAC BLIMP-1 degrader-1

PROTAC BLIMP-1 degrader-1 (Compound 49) is a PROTAC-based BLIMP-1 degrader. PROTAC BLIMP-1 degrader-1 promotes the ubiquitination and degradation of BLIMP-1 and can be used in research on myeloproliferative tumors.
(Pink: Ligands for Target Protein for PROTAC ligand (HY-180178); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-W442918); Black: linker (HY-180180)).

For research use only. We do not sell to patients.

Formula: C₄₁H₄₇BrN₈O₄
Molecular Weight:795.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC BLIMP-1 degrader-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BLIMP-1 degrader-1 (Compound 49) is a PROTAC-based BLIMP-1 degrader. PROTAC BLIMP-1 degrader-1 promotes the ubiquitination and degradation of BLIMP-1 and can be used in research on myeloproliferative tumors^[1]. (Pink: Ligands for Target Protein for PROTAC ligand (HY-180178); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-W442918); Black: linker (HY-180180)).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 795.77
Formula C₄₁H₄₇BrN₈O₄
SMILES

CC1=CC(Br)=CC=C1[C@@H](C(N)=O)N2CCN3N=C(C=C3C2)CNC(C4=NC(C)=C([C@H]5CC[C@@H](CC5)CNC6=CC=C(C7CCC(NC7=O)=O)C=C6)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Simmons BJ, et al. Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders. J Med Chem. 2025 Dec 11;68(23):25385-25402. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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PROTAC BLIMP-1 degrader-1

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BLIMP-1 degrader-1 Related Classifications

HY-180177 Related Classifications