STING Degrader-1
STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM.
For research use only. We do not sell to patients.
- Formula: C26H24N4O7
- Molecular Weight:504.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Chemical Information
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Molecular Weight 504.49
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Formula C26H24N4O7
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SMILES
O=C(NC1=CC=C(N2CCN(C(/C=C/C(C3=CC=C(OC)C=C3)=O)=O)CC2)C=C1)C4=CC=C([N+]([O-])=O)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Hot Topics
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Topics
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Topics Targeted Protein Degradation (TPD): From PROTACs to Molecular Glues
Targeted protein degradation is a drug discovery strategy that uses cellular protein degradation systems to selectively eliminate disease-associated proteins, and its core modalities include PROTACs and molecular glue degraders.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)