1. PROTAC
    Epigenetics
  2. PROTACs
    Histone Methyltransferase
  3. PROTAC EZH2 Degrader-1

PROTAC EZH2 Degrader-1 

Cat. No.: HY-147525 Purity: 98.55%
COA Handling Instructions

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes.

For research use only. We do not sell to patients.

PROTAC EZH2 Degrader-1 Chemical Structure

PROTAC EZH2 Degrader-1 Chemical Structure

CAS No. : 2641601-67-2

Size Price Stock Quantity
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].

IC50 & Target

EZH2

2.7 nM (IC50)

Molecular Weight

942.15

Formula

C54H67N7O8

CAS No.
SMILES

CCN(C1CCOCC1)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (106.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0614 mL 5.3070 mL 10.6140 mL
5 mM 0.2123 mL 1.0614 mL 2.1228 mL
10 mM 0.1061 mL 0.5307 mL 1.0614 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC EZH2 Degrader-1
Cat. No.:
HY-147525
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