2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. PROTAC EZH2 Degrader-1

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes.

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PROTAC EZH2 Degrader-1 Chemical Structure

PROTAC EZH2 Degrader-1 Chemical Structure

CAS No. : 2641601-67-2

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10 mg USD 980 In-stock
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50 mg USD 3300 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC EZH2 Degrader-1 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].

IC50 & Target

EZH2

2.7 nM (IC50)

Molecular Weight

942.15

Formula

C54H67N7O8
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCN(C1CCOCC1)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (106.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0614 mL 5.3070 mL 10.6140 mL
5 mM 0.2123 mL 1.0614 mL 2.1228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0614 mL 5.3070 mL 10.6140 mL 26.5351 mL
5 mM 0.2123 mL 1.0614 mL 2.1228 mL 5.3070 mL
10 mM 0.1061 mL 0.5307 mL 1.0614 mL 2.6535 mL
15 mM 0.0708 mL 0.3538 mL 0.7076 mL 1.7690 mL
20 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
25 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0614 mL
30 mM 0.0354 mL 0.1769 mL 0.3538 mL 0.8845 mL
40 mM 0.0265 mL 0.1327 mL 0.2654 mL 0.6634 mL
50 mM 0.0212 mL 0.1061 mL 0.2123 mL 0.5307 mL
60 mM 0.0177 mL 0.0885 mL 0.1769 mL 0.4423 mL
80 mM 0.0133 mL 0.0663 mL 0.1327 mL 0.3317 mL
100 mM 0.0106 mL 0.0531 mL 0.1061 mL 0.2654 mL
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PROTAC EZH2 Degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EZH2 Degrader-12641601-67-2PROTACsHistone MethyltransferasePROTAC EZH2 DegraderEZH2 methyltransferase activitytumorigenesisPolycomb repressive complex 2PRC2Inhibitorinhibitorinhibit

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