PROTAC LZK degrader 1
PROTAC LZK degrader 1 (Compound 21A) is a PROTAC that targets the degradation of LZK (Leucine Zipper Kinase, encoded by MAP3K13). PROTAC LZK degrader 1 (10 μM) promotes the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. PROTAC LZK degrader 1 can be used in cancer research[1].
(Pink: MAP3K13/LZK Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker (HY-W019543)).
For research use only. We do not sell to patients.
- CAS No.: 2763268-64-8
- Formula: C51H64F2N10O5S
- Molecular Weight:967.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2763268-64-8
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Molecular Weight 967.18
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Formula C51H64F2N10O5S
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SMILES
FC(CC1)(F)CN1C2=CC(C3CCN(C(CCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=CC(NC7=CC(C#N)=CC=N7)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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