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Cat. No.: HY-170596

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LZK ligand-1

LZK ligand-1 is a LZK ligand, which can be used for the synthesis of PROTACs, such as PROTAC LZK degrader 1 (HY-170595).

For research use only. We do not sell to patients.

CAS No.: 2763269-16-3
Formula: C₂₀H₂₂F₂N₆
Molecular Weight:384.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LZK ligand-1 Chemical Structure

CAS No.: 2763269-16-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

LZK ligand-1 is a LZK ligand, which can be used for the synthesis of PROTACs, such as PROTAC LZK degrader 1 (HY-170595)^[1].

IC₅₀ & Target

MAP3K13/LZK

All MAP3K Isoforms :

Chemical Information

CAS No. 2763269-16-3
Molecular Weight 384.43
Formula C₂₀H₂₂F₂N₆
SMILES

FC(CC1)(F)CN1C2=CC(C3CCNCC3)=CC(NC4=CC(C#N)=CC=N4)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Funk AL, et al. Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.623840. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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LZK ligand-1

All MAP3K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LZK ligand-1 Related Classifications

HY-170596 Related Classifications