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Cat. No.: HY-146368

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PROTAC VEGFR-2 degrader-1

PROTAC VEGFR-2 degrader-1 is a VEGFR-2-targeting PROTAC with >1 μM IC₅₀ against VEGFR-2, >100 μM IC₅₀ against endothelial cell proliferation, and no significant cytotoxicity against embryonic kidney cells. PROTAC VEGFR-2 degrader-1 can be used for the research of cancer.
(Pink: VEGFR2 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker (HY-Y1139)).

For research use only. We do not sell to patients.

CAS No.: 2601594-19-6
Formula: C₅₂H₆₁N₉O₆S
Molecular Weight:940.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC VEGFR-2 degrader-1 Chemical Structure

CAS No.: 2601594-19-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC VEGFR-2 degrader-1 is a VEGFR-2-targeting PROTAC with >1 μM IC₅₀ against VEGFR-2, >100 μM IC₅₀ against endothelial cell proliferation, and no significant cytotoxicity against embryonic kidney cells. PROTAC VEGFR-2 degrader-1 can be used for the research of cancer^[1]. (Pink: VEGFR2 Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker (HY-Y1139)).

IC₅₀ & Target^[1]

VEGFR2

VHL

All PROTACs Isoforms :

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
EA.hy 926	IC₅₀	>100 μM Compound: PROTAC-1	Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay	[PMID: 32750566]

In Vitro

PROTAC VEGFR-2 degrader-1 (PROTAC-1) (1 h) inhibits purified VEGFR-2 kinase with an IC₅₀ greater than 1 μM^[1].
PROTAC VEGFR-2 degrader-1 (24 h) inhibits EA.hy926 cell proliferation with an IC₅₀ greater than 100 μM^[1].
PROTAC VEGFR-2 degrader-1 (100 μM) shows no significant cytotoxicity against HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2601594-19-6
Molecular Weight 940.16
Formula C₅₂H₆₁N₉O₆S
SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2N=C(N)C3=C2C=CC=C3C4=CC=CC(NC(NC5=CC=CC(C(C)C)=C5)=O)=C4)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shan Y, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. European journal of medicinal chemistry. 2020 Nov 01;205:112654. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC VEGFR-2 degrader-1

All PROTACs Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC VEGFR-2 degrader-1 Related Classifications

HY-146368 Related Classifications