2601594-19-6
Chemical Structure
PROTAC VEGFR-2 degrader-1
- CAS No.: 2601594-19-6
- Formula:C52H61N9O6S
- Molecular Weight:940.16
IUPAC Name: 2,3-dibromobenzofuran
InChIKey: XCMSXWSOOSQEDL-PDZNDIJHSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2N=C(N)C3=C2C=CC=C3C4=CC=CC(NC(NC5=CC=CC(C(C)C)=C5)=O)=C4)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
Biological Activity: PROTAC VEGFR-2 degrader-1 is a VEGFR-2-targeting PROTAC with >1 μM IC50 against VEGFR-2, >100 μM IC50 against endothelial cell proliferation, and no significant cytotoxicity against embryonic kidney cells. PROTAC VEGFR-2 degrader-1 can be used for the research of cancer[1].
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PROTAC VEGFR-2 degrader-1 | PROTAC VEGFR-2 degrader-1 is a VEGFR-2-targeting PROTAC with >1 μM IC50 against VEGFR-2, >100 μM IC50 against endothelial cell proliferation, and no significant cytotoxicity against embryonic kidney cells. PROTAC VEGFR-2 degrader-1 can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
