SHP2 protein degrader-1
Based on 1 Customer Validation
SHP2 protein degrader-1 is a potent SHP2 PROTAC degrader with an IC50 of 0.714 μM. SHP2 protein degrader-1 inhibits cancer cell growth and induces apoptosis. SHP2 protein degrader-1 can be used in cervical adenocarcinoma research.
(Pink: SHP2 ligand (HY-176795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-128834)).
For research use only. We do not sell to patients.
- Purity: 98.94%
- CAS No.: 2624181-69-5
- Formula: C42H51Cl2N11O8
- Molecular Weight:908.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
4.3 μM
Compound: 9; SP4
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 38788299] |
SHP2 protein degrader-1 (Compound SP4) (0-200 μM; 96 h) potently inhibits the proliferation of HeLa cells, with an IC50 value of 4.30 nM[1].
SHP2 protein degrader-1 (1-100 nM; 96 h) induces dose-dependent activation of apoptotic markers and inhibits RAS/MAPK pathway signaling in HeLa cells[1].
SHP2 protein degrader-1 (1-100 nM; 96 h) induces apoptosis in HeLa cells[1].
SHP2 protein degrader-1 (1-100 nM; 96 h) induces dose-dependent G1 phase cell cycle arrest in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:1,10 and 100 nM
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Incubation Time:96 h
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Result:Induced dose-dependent cleavage of PARP, caspase-3, and caspase-9, while reducing levels of the anti-apoptotic protein Bcl-xL.
Inhibited dose-dependent phosphorylation of JNK, Erk, and p38, key kinases in the RAS/MAPK signaling pathway.
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Cell Line:HeLa cells
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Concentration:1,10 and 100 nM
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Incubation Time:96 h
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Result:Induced 54.01% apoptotic cell death at 100 nM, a significantly higher rate than the reference inhibitor SHP099 at 1000 nM (33.74%).
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Cell Line:HeLa cells
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Concentration:1,10 and 100 nM
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Incubation Time:96 h
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Result:Induced dose-dependent cell cycle arrest at the G1 phase in HeLa cells.
Chemical Information
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CAS No. 2624181-69-5
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Appearance Solid
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Molecular Weight 908.83
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Formula C42H51Cl2N11O8
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Color Light yellow to yellow
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SMILES
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCOCCN4N=NC(CNC5(CCN(CC5)C6=CN=C(C7=C(Cl)C(Cl)=CC=C7)C(N)=N6)C)=C4)=CC=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 110 mg/mL (121.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1003 mL | 5.5016 mL | 11.0032 mL | 27.5079 mL |
| 5 mM | 0.2201 mL | 1.1003 mL | 2.2006 mL | 5.5016 mL | |
| 10 mM | 0.1100 mL | 0.5502 mL | 1.1003 mL | 2.7508 mL | |
| 15 mM | 0.0734 mL | 0.3668 mL | 0.7335 mL | 1.8339 mL | |
| 20 mM | 0.0550 mL | 0.2751 mL | 0.5502 mL | 1.3754 mL | |
| 25 mM | 0.0440 mL | 0.2201 mL | 0.4401 mL | 1.1003 mL | |
| 30 mM | 0.0367 mL | 0.1834 mL | 0.3668 mL | 0.9169 mL | |
| 40 mM | 0.0275 mL | 0.1375 mL | 0.2751 mL | 0.6877 mL | |
| 50 mM | 0.0220 mL | 0.1100 mL | 0.2201 mL | 0.5502 mL | |
| 60 mM | 0.0183 mL | 0.0917 mL | 0.1834 mL | 0.4585 mL | |
| 80 mM | 0.0138 mL | 0.0688 mL | 0.1375 mL | 0.3438 mL | |
| 100 mM | 0.0110 mL | 0.0550 mL | 0.1100 mL | 0.2751 mL |
SHP2 protein degrader-1 Related Classifications
HY-145159 Related Classifications
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