2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. PROTAC CDK2/4 Degrader-1

PROTAC CDK2/4 Degrader-1 (Compound 5) is a CDK2/4 PROTAC degrader, with its DC50 values for CDK2 and CDK4 both ≤ 10 nM. PROTAC CDK2/4 Degrader-1 exhibits excellent inhibitory activity against cell proliferation in OVCAR3 and T47D cells. PROTAC CDK2/4 Degrader-1 can be used for research on breast cancer and ovarian cancer.
(Pink: CDK2 and CDK4 ligand (HY-W1047040); Blue: Cereblon ligand (HY-W883326); Black: linker).

For research use only. We do not sell to patients.

PROTAC CDK2/4 Degrader-1

PROTAC CDK2/4 Degrader-1 Chemical Structure

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PROTAC CDK2/4 Degrader-1 Related Antibodies

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Description

PROTAC CDK2/4 Degrader-1 (Compound 5) is a CDK2/4 PROTAC degrader, with its DC50 values for CDK2 and CDK4 both ≤ 10 nM. PROTAC CDK2/4 Degrader-1 exhibits excellent inhibitory activity against cell proliferation in OVCAR3 and T47D cells. PROTAC CDK2/4 Degrader-1 can be used for research on breast cancer and ovarian cancer[1]. (Pink: CDK2 and CDK4 ligand (HY-W1047040); Blue: Cereblon ligand (HY-W883326); Black: linker).

IC50 & Target[1]

CDK2

≤ 10 nM (DC50)

CDK4

≤ 10 nM (DC50)

Cereblon

 

Molecular Weight

675.75

Formula

C30H39F2N9O5S
SMILES

O=S(NCCN(CC1)CCC1C(C=C2)=CC3=C2C(C(CC4)C(NC4=O)=O)=NN3C)(N5CCC(NC6=NC=C(OC(F)F)C=N6)CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC CDK2/4 Degrader-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC CDK2/4 Degrader-1PROTACsCDKCyclin dependent kinaseprotein degradationanticancer agentskinase inhibitorsE3 ubiquitin ligase ligandspharmaceutical compositionscombination therapycancer treatmentInhibitorinhibitorinhibit

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PROTAC CDK2/4 Degrader-1
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