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Cat. No.: HY-178515

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Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine

Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine can be used for synthesizing PROTAC CDK4/6/9 degrader 1 (HY-178452).

For research use only. We do not sell to patients.

Formula: C₃₄H₄₇N₇O₇
Molecular Weight:665.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

Molecular Weight 665.78
Formula C₃₄H₄₇N₇O₇
SMILES

O=C(C(CC1)N(C2=O)C(C(C2=C3)=CC=C3N(CC4)CCN4C(CN(CC5)CCC5CN(CC6)CCN6C(OC(C)(C)C)=O)=O)=O)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68(19):20464-20486. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine

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Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine Related Classifications

HY-178515 Related Classifications

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Keywords

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