Pomalidomide 5'-pip-acid 

Pomalidomide 5'-pip-acid is an E3 ligase ligand-linker conjugate derived from the molecular glue Pomalidomide (HY-10984), which can be used to synthesize the dual-target PROTAC degrader PROTAC CBP/p300/BRD4 Degrader-1 (HY-181758) targeting CBP/p300 and BRD4. Pomalidomide 5'-pip-acid shows anti-proliferative activity against cancer cells with an IC₅₀ of 2.73 nM. Pomalidomide 5'-pip-acid induces anti-proliferative effects in cancer cells. Pomalidomide 5'-pip-acid is applicable to research related to prostate cancer and colorectal cancer^[1].

Derivatives of Pomalidomide 5'-pip-acid potently inhibit the proliferation of human prostate cancer cell line PC-3 in vitro, with IC₅₀ values ranging from 2.73 nM to 24.77 nM. Among them, the most active compound has an IC₅₀ of 2.73 nM^[1].
Derivatives of Pomalidomide 5'-pip-acid (5-20 nM; 12 h) effectively degrade BRD4 protein in human prostate cancer PC-3 cells at concentrations of 5 nM and 20 nM after 12 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Derivative of Pomalidomide 5'-pip-acid (0.1-0.2 mg/kg; i.p.; once every 2 days; 24 days) achieve dose-dependent tumor growth inhibition in the PC-3 xenograft mouse model, with a maximum inhibition rate of up to 81.5% at the dose of 0.2 mg/kg, and exhibit favorable preliminary safety profiles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

385.37

C₁₉H₁₉N₃O₆

2467965-70-2

Solid

Light yellow to yellow

O=C(C1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1)O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Zhang YZ, et al. Discovery of Novel CBP/p300 and BRD4 Dual-Target PROTACs with Potent Antitumor Activity in Prostate Cancer. J Med Chem. 2026;69(4):4512-4547.  [Content Brief]