Pomalidomide 5'-pip-acid
Based on 1 Customer Validation
Pomalidomide 5'-pip-acid is an E3 ligase ligand-linker conjugate derived from the molecular glue Pomalidomide (HY-10984), which can be used to synthesize the dual-target PROTAC degrader PROTAC CBP/p300/BRD4 Degrader-1 (HY-181758) targeting CBP/p300 and BRD4. Pomalidomide 5'-pip-acid shows anti-proliferative activity against cancer cells with an IC50 of 2.73 nM. Pomalidomide 5'-pip-acid induces anti-proliferative effects in cancer cells. Pomalidomide 5'-pip-acid is applicable to research related to prostate cancer and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 98.06%
- CAS No.: 2467965-70-2
- Formula: C19H19N3O6
- Molecular Weight:385.37
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Derivatives of Pomalidomide 5'-pip-acid potently inhibit the proliferation of human prostate cancer cell line PC-3 in vitro, with IC50 values ranging from 2.73 nM to 24.77 nM. Among them, the most active compound has an IC50 of 2.73 nM[1].
Derivatives of Pomalidomide 5'-pip-acid (5-20 nM; 12 h) effectively degrade BRD4 protein in human prostate cancer PC-3 cells at concentrations of 5 nM and 20 nM after 12 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2467965-70-2
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Appearance Solid
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Molecular Weight 385.37
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Formula C19H19N3O6
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Color Light yellow to yellow
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SMILES
O=C(C1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pomalidomide 5'-pip-acid Related Classifications
HY-W877997 Related Classifications
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