JNK1 degrader-1

JNK1 degrader-1 (HY12) (10-100 nM; 5 h) inhibits the kinase activity of purified JNK1, with an inhibition rate of 86.01% at 100 nM and 59.55% at 10 nM^[1].
JNK1 degrader-1 (1 μM; 24-48 h) induces potent, dose- and time-dependent degradation of JNK1 in BEAS-2B cells via the ubiquitin-proteasome system and autophagy-lysosome pathway, with a DC₅₀ of 0.16 μM and a degradation rate of 70.40% after treatment at 1 μM for 48 h^[1].
JNK1 degrader-1 (1 μM; 48 h) selectively degrades JNK1 in BEAS-2B cells, with no significant effects on the protein levels of JNK2, p38 or ERK^[1].
JNK1 degrader-1 (0.1-1 μM; 1 h pre-treatment, 48 h total) inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cells, reverses the upregulation of mesenchymal markers and downregulation of epithelial markers at a concentration of 0.1 μM, and suppresses TGF-β1-induced JNK1 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.