PROTAC Akt3 Degrader-1 

PROTAC Akt3 Degrader-1 is a highly efficient and selective PROTAC degrader targeting Akt3. PROTAC Akt3 Degrader-1 shows weak antiproliferative activity in 36 cell lines. PROTAC Akt3 Degrader-1 can be used for the study of Triple-negative breast cancer and melanoma^[1]. (Pink: Akt3 ligand (HY-175976); Blue: Cereblon ligand (HY-43722); Black: linker).

PROTAC Akt3 Degrader-1 (Compound 12) (0.2 nM-5 μM, 24 h) effectively induces Akt3 degradation in MDA-MB-468 cells (DC₅₀ = 7.5 nM), but shows no significant degradation of Akt1 and Akt2 (DC₅₀ > 5000 nM)^[1].
PROTAC Akt3 Degrader-1 (0.2 μM, 24 h) is a highly specific Akt3 degrader, significantly reducing only Akt3 and TMEM120B proteins in MDA-MB-468 cells with minimal off-target effects^[1].
PROTAC Akt3 Degrader-1 (0.2 nM-5 μM, 24 h) induces Akt3 degradation at a DC₅₀ of 7.0 nM in MDA-MB-231 cells and at 54.3 nM in A-375 cells^[1].
PROTAC Akt3 Degrader-1 shows IC₅₀ values of > 30 μM and 13.5 μM in MDA-MB-468 and MDA-MB-231 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

851.43

C₄₆H₅₅ClN₈O₆

3048204-93-6

O=C1NC2=NC=NC(N3[C@H]4C[C@H]4N(CC3)C([C@@H](C5=CC=C(C=C5)Cl)CNC(CCCCCCCCCCC6=C(C7=CC=C6)CN(C7=O)C8CCC(NC8=O)=O)=O)=O)=C2[C@@H](C1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu YB, et al. Design, Synthesis, and Biological Evaluation of Isoform-Selective Akt3 Degraders. J Med Chem. 2025 Sep 11;68(17):18272-18288.  [Content Brief]