Akt3 Degrader
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Akt3 degrader 1
0 ImagesCat. No.: HY-151606CAS No.: 2836342-69-7Akt3 degrader 1 is an orally active selective Akt3 degrader with a DC50 of 13 nM. Akt3 degrader 1 binds to the PH domain of Akt3 to trigger proteasome-mediated degradation, with minimal effects on Akt1/Akt2. Akt3 degrader 1 inhibits cancer cell growth. Akt3 degrader 1 can be used for the research of non-small cell lung cancer.
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MS143
0 ImagesCat. No.: HY-143883CAS No.: 2376137-41-4MS143 is a VHL-recruiting AKT protein PROTAC degrader with a DC50 of 46 nM in PC3 prostate cancer cells. MS143 preferentially binds to AKT1 and AKT3, with weaker binding activity towards AKT2. MS143 degrades AKT and blocks the phosphorylation of downstream signaling molecules in the PI3K/AKT/mTOR pathway. MS143 inhibits cancer cell growth and xenograft tumor growth. MS143 can be used for research on prostate cancer, triple-negative breast cancer, and breast cancer.
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PROTAC Akt3 Degrader-1
0 ImagesCat. No.: HY-175975CAS No.: 3048204-93-6
