2836342-69-7
Chemical Structure
Akt3 degrader 1
- CAS No.: 2836342-69-7
- Formula:C53H72N8O4
- Molecular Weight:885.19
IUPAC Name: N-(3-(2-((4-(4-(12-(2-(adamantan-1-yl)acetamido)dodecyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)cyclopropanecarboxamide
InChIKey: KLSALARRZCZNDM-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(N2CCN(CC2)CCCCCCCCCCCCNC(CC34CC5CC(C4)CC(C3)C5)=O)=C1)NC6=NC=C7C(C)=CC(N(C7=N6)C8=CC=CC(NC(C9CC9)=O)=C8)=O
Biological Activity: Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that overcomesOsimertinib (HY-15772)-induced resistance in H1975OR NSCLC cells. Akt3 degrader 1 also has anti-proliferative activity and significantly inhibits tumour growth in mice. Akt3 degrader 1 can be used in the study of drug-resistant non-small cell lung cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Akt3 degrader 1 | 95.10% | Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that overcomesOsimertinib (HY-15772)-induced resistance in H1975OR NSCLC cells. Akt3 degrader 1 also has anti-proliferative activity and significantly inhibits tumour growth in mice. Akt3 degrader 1 can be used in the study of drug-resistant non-small cell lung cancer. | ||||||||||||||||||||
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Keywords
