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Cat. No.: HY-168017

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NSC682769

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016).

For research use only. We do not sell to patients.

CAS No.: 205048-79-9
Formula: C₂₇H₂₂N₂O₃
Molecular Weight:422.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

NSC682769 Chemical Structure

CAS No.: 205048-79-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016)^[1].

All YAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	69 μM Compound: 6 : NSC682769	Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]
NCI-H226	IC₅₀	3.9 μM Compound: 6 : NSC682769	Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]

Chemical Information

CAS No. 205048-79-9
Molecular Weight 422.48
Formula C₂₇H₂₂N₂O₃
SMILES

O=C1NC2=CC=CC=C2C3=NC(C4=CC=CC=C4)=CC(C(C=C5OC)=CC=C5OC)=C3C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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