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  3. PROTAC BRD9 Degrader-1

PROTAC BRD9 Degrader-1 

Cat. No.: HY-103632 Purity: 99.37%
Handling Instructions

PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology.

For research use only. We do not sell to patients.

PROTAC BRD9 Degrader-1 Chemical Structure

PROTAC BRD9 Degrader-1 Chemical Structure

CAS No. : 2097971-01-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1492 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology[1].

IC50 & Target

BRD9

13.5 nM (IC50)

BRD4

3.78 μM (IC50)

CRBN-DDB1

48.9 nM (IC50)

In Vitro

PROTAC BRD9 Degrader-1 (Compound 1) inhibits BRD9, BRD4, and CRBN-DDB1 with IC50s of 13.5 nM, 3.78 μM, and 48.9 nM, respectively[1].

Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (165.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1062 mL 5.5311 mL 11.0622 mL
5 mM 0.2212 mL 1.1062 mL 2.2124 mL
10 mM 0.1106 mL 0.5531 mL 1.1062 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

903.98

Formula

C₄₂H₄₅N₇O₁₂S₂

CAS No.

2097971-01-0

SMILES

O=C1C(C=C(C(NC(CC2)CCS2(=O)=O)=N)S3)=C3C(C4=CC(OC)=C(OCC(NCCCCNC(COC5=C(C(N6C(CCC7=O)C(N7)=O)=O)C(C6=O)=CC=C5)=O)=O)C=C4)=CN1C

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PROTAC BRD9 Degrader-1
Cat. No.:
HY-103632
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PROTAC BRD9 Degrader-1

Cat. No.: HY-103632