2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Histone Methyltransferase
  4. MAK683-CH2CH2COOH hydrochloride

MAK683-CH2CH2COOH hydrochloride 

Cat. No.: HY-130815A Purity: 97.60%
COA Handling Instructions

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MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).

For research use only. We do not sell to patients.

MAK683-CH2CH2COOH hydrochloride Chemical Structure

MAK683-CH2CH2COOH hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1680 In-stock
50 mg USD 2650 In-stock
100 mg USD 4200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MAK683-CH2CH2COOH hydrochloride:

MAK683-CH2CH2COOH hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].

In Vitro

MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAK683-CH2CH2COOH hydrochloride Related Antibodies
Molecular Weight

484.91

Formula

C23H22ClFN6O3
Appearance

Solid

Color

White to light yellow

SMILES

[H]Cl.FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0622 mL 10.3112 mL 20.6224 mL
5 mM 0.4124 mL 2.0622 mL 4.1245 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0622 mL 10.3112 mL 20.6224 mL 51.5560 mL
5 mM 0.4124 mL 2.0622 mL 4.1245 mL 10.3112 mL
10 mM 0.2062 mL 1.0311 mL 2.0622 mL 5.1556 mL
15 mM 0.1375 mL 0.6874 mL 1.3748 mL 3.4371 mL
20 mM 0.1031 mL 0.5156 mL 1.0311 mL 2.5778 mL
25 mM 0.0825 mL 0.4124 mL 0.8249 mL 2.0622 mL
30 mM 0.0687 mL 0.3437 mL 0.6874 mL 1.7185 mL
40 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2889 mL
50 mM 0.0412 mL 0.2062 mL 0.4124 mL 1.0311 mL
60 mM 0.0344 mL 0.1719 mL 0.3437 mL 0.8593 mL
80 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.6444 mL
100 mM 0.0206 mL 0.1031 mL 0.2062 mL 0.5156 mL
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MAK683-CH2CH2COOH hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAK683-CH2CH2COOHLigands for Target Protein for PROTACHistone MethyltransferaseTarget Protein-binding MoietyembryonicectodermdevelopmentE3ubiquitinligaseInhibitorinhibitorinhibit

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