MAK683-C2-acid hydrochloride
Based on 1 Customer Validation
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).
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- Pureté: 99.60%
- CAS No.: 2938997-23-8
- Formule: C23H22ClFN6O3
- Masse moléculaire:484.91
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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Histone Modification Research Compound Library
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Anti-Cancer Compound Library
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Reprogramming Compound Library
HY-L039
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Anti-Blood Cancer Compound Library
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Target Protein Ligand Library
HY-L129
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Anti-Hematopathy Compound Library
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MCE Bioactive Compound Library
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Methylation Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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Voir tous les produits spécifiques à Isoform Histone Methyltransferase
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Activité biologique
MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2938997-23-8
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Appearance Solid
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Masse moléculaire 484.91
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Formule C23H22ClFN6O3
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Color White to light yellow
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SMILES
FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvant et solubilité
DMSO : 50 mg/mL (103.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0622 mL | 10.3112 mL | 20.6224 mL | 51.5560 mL |
| 5 mM | 0.4124 mL | 2.0622 mL | 4.1245 mL | 10.3112 mL | |
| 10 mM | 0.2062 mL | 1.0311 mL | 2.0622 mL | 5.1556 mL | |
| 15 mM | 0.1375 mL | 0.6874 mL | 1.3748 mL | 3.4371 mL | |
| 20 mM | 0.1031 mL | 0.5156 mL | 1.0311 mL | 2.5778 mL | |
| 25 mM | 0.0825 mL | 0.4124 mL | 0.8249 mL | 2.0622 mL | |
| 30 mM | 0.0687 mL | 0.3437 mL | 0.6874 mL | 1.7185 mL | |
| 40 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2889 mL | |
| 50 mM | 0.0412 mL | 0.2062 mL | 0.4124 mL | 1.0311 mL | |
| 60 mM | 0.0344 mL | 0.1719 mL | 0.3437 mL | 0.8593 mL | |
| 80 mM | 0.0258 mL | 0.1289 mL | 0.2578 mL | 0.6444 mL | |
| 100 mM | 0.0206 mL | 0.1031 mL | 0.2062 mL | 0.5156 mL |
MAK683-C2-acid hydrochloride Related Classifications
HY-130815A Related Classifications
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