1. Epigenetics
    PROTAC
  2. Histone Methyltransferase
    Ligand for Target Protein for PROTAC
  3. MAK683-CH2CH2COOH

MAK683-CH2CH2COOH 

Cat. No.: HY-130815
Handling Instructions

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).

For research use only. We do not sell to patients.

MAK683-CH2CH2COOH Chemical Structure

MAK683-CH2CH2COOH Chemical Structure

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Description

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].

In Vitro

MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].

Molecular Weight

448.45

Formula

C₂₃H₂₁FN₆O₃

SMILES

FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MAK683-CH2CH2COOHHistone MethyltransferaseLigand for Target Protein for PROTACTarget Protein-binding MoietyembryonicectodermdevelopmentE3ubiquitinligaseInhibitorinhibitorinhibit

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Product name:
MAK683-CH2CH2COOH
Cat. No.:
HY-130815
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