1. Epigenetics PROTAC
  2. Histone Methyltransferase Ligands for Target Protein for PROTAC
  3. MAK683-CH2CH2COOH

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MAK683-CH2CH2COOH hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

MAK683-CH2CH2COOH Chemical Structure

MAK683-CH2CH2COOH Chemical Structure

CAS No. : 2639882-68-9

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Description

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].

In Vitro

MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

448.45

Formula

C23H21FN6O3

CAS No.
SMILES

FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(O)=O)C=C4)C5=NN=CN35

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MAK683-CH2CH2COOH
Cat. No.:
HY-130815
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