Cyclin K degrader 1
Based on 1 Customer Validation
Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM. Cyclin K degrader 1 has an affinity for cyclin K that is ~500-fold higher than its affinity for CDK12.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 3055008-98-2
- Formula: C23H17Cl2N5O2
- Molecular Weight:466.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Cyclin K degrader 1(1 μM, 2 h) degrades Cyclin K with presence of DDB-1[1].
Cyclin K degrader 1(1 μM, 2 h) degrades 99 ± 1 % Cyclin K, with DC50 of 21 nM, Dmax >95% and CDK12 Kd of 1000 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3055008-98-2
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Appearance Solid
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Molecular Weight 466.32
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Formula C23H17Cl2N5O2
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Color White to off-white
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SMILES
O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (214.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1445 mL | 10.7223 mL | 21.4445 mL | 53.6113 mL |
| 5 mM | 0.4289 mL | 2.1445 mL | 4.2889 mL | 10.7223 mL | |
| 10 mM | 0.2144 mL | 1.0722 mL | 2.1445 mL | 5.3611 mL | |
| 15 mM | 0.1430 mL | 0.7148 mL | 1.4296 mL | 3.5741 mL | |
| 20 mM | 0.1072 mL | 0.5361 mL | 1.0722 mL | 2.6806 mL | |
| 25 mM | 0.0858 mL | 0.4289 mL | 0.8578 mL | 2.1445 mL | |
| 30 mM | 0.0715 mL | 0.3574 mL | 0.7148 mL | 1.7870 mL | |
| 40 mM | 0.0536 mL | 0.2681 mL | 0.5361 mL | 1.3403 mL | |
| 50 mM | 0.0429 mL | 0.2144 mL | 0.4289 mL | 1.0722 mL | |
| 60 mM | 0.0357 mL | 0.1787 mL | 0.3574 mL | 0.8935 mL | |
| 80 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6701 mL | |
| 100 mM | 0.0214 mL | 0.1072 mL | 0.2144 mL | 0.5361 mL |
Cyclin K degrader 1 Related Classifications
HY-161168 Related Classifications
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