3055008-98-2
Chemical Structure
Cyclin K degrader 1
- CAS No.: 3055008-98-2
- Formula:C23H17Cl2N5O2
- Molecular Weight:466.32
InChIKey: DCPUWHPUJFAXLO-UHFFFAOYSA-N
SMILES: O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4
Biological Activity: Cyclin K degrader 1 is a molecular glue degrader derived from the pan-CDK inhibitor AT-7519 (HY-50940), with potent Cyclin K degrading activity and a DC50 of 21 nM. Cyclin K degrader 1 binds to CDK12, mediates the formation of a CDK12-DDB1 ternary protein complex, recruits the E3 ubiquitin ligase complex, and induces ubiquitination and proteasomal degradation of Cyclin K. Cyclin K degrader 1 can be used in the research of various Cyclin K-related diseases such as cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclin K degrader 1 | 99.70% | Cyclin K degrader 1 is a molecular glue degrader derived from the pan-CDK inhibitor AT-7519 (HY-50940), with potent Cyclin K degrading activity and a DC50 of 21 nM. Cyclin K degrader 1 binds to CDK12, mediates the formation of a CDK12-DDB1 ternary protein complex, recruits the E3 ubiquitin ligase complex, and induces ubiquitination and proteasomal degradation of Cyclin K. Cyclin K degrader 1 can be used in the research of various Cyclin K-related diseases such as cancer. | ||||||||||||||||||||
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-
Similarity Score 0.74
HY-146276CDK/HDAC-IN-2 -
Similarity Score 0.65
HY-149819CDK/HDAC-IN-3 -
Similarity Score 0.58
HY-50940RAT7519 (Standard) -
Similarity Score 0.57
HY-50943RAT7519 Hydrochloride (Standard) -
Similarity Score 0.56
HY-170979CDK9 ligand 3 -
Similarity Score 0.55
HY-149208HDAC-IN-53 -
Similarity Score 0.55
HY-50940AAT7519 TFA -
Similarity Score 0.53
HY-170306LZ9 -
Similarity Score 0.52
HY-149946HDAC-IN-57 -
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