LZ9
LZ9 is a ATP-competitive CDK1 and CDK2 inhibitor. LZ9 has the potential for the research of colorectal cancer (CRC).
For research use only. We do not sell to patients.
- CAS No.: 844441-29-8
- Formula: C17H11F3N4O2
- Molecular Weight:360.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
CDK1 |
cyclin B1/CDC2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2058 | IC50 |
1.011 μM
Compound: DC-K2in2
|
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
|
[PMID: 33611192] |
| A-375 | IC50 |
13.38 μM
Compound: 1
|
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
| HCT-116 | IC50 |
1.4 μM
Compound: 23
|
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
|
[PMID: 18656911] |
| HCT-116 | IC50 |
1.4 μM
Compound: 8d
|
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
|
[PMID: 26115571] |
| HCT-116 | IC50 |
1.96 μM
Compound: 1
|
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
| HeLa | IC50 |
8.23 μM
Compound: 1
|
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 31991336] |
| NCI-H460 | IC50 |
9.46 μM
Compound: 1
|
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
| SMMC-7721 | IC50 |
23.21 μM
Compound: 1
|
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
Chemical Information
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CAS No. 844441-29-8
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Molecular Weight 360.29
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Formula C17H11F3N4O2
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SMILES
O=C(C1=NNC=C1NC(C2=C(F)C=CC=C2F)=O)NC3=CC=C(C=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lu Z, et al. Computational design of CDK1 inhibitors with enhanced target affinity and drug-likeness using deep-learning framework. Heliyon. 2024 Nov 14;10(22):e40345. [Content Brief]
[2]. Ogbodo UC, et al. Computational identification of potential inhibitors targeting cdk1 in colorectal cancer. Front Chem. 2023 Nov 30;11:1264808. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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