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Cat. No.: HY-185575

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ATM ligand-1

ATM ligand-1 is an ATM ligand that can be used for the synthesis of PROTACs, such as PROTAC ATM degrader-1 (HY-158345).

For research use only. We do not sell to patients.

CAS No.: 3056059-49-2
Formula: C₁₉H₁₂N₂O₂
Molecular Weight:300.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ATM ligand-1 Chemical Structure

CAS No.: 3056059-49-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

ATM ligand-1 is an ATM ligand that can be used for the synthesis of PROTACs, such as PROTAC ATM degrader-1 (HY-158345).

IC₅₀ & Target^[1]

ATM

All ATM/ATR Isoforms :

Chemical Information

CAS No. 3056059-49-2
Molecular Weight 300.31
Formula C₁₉H₁₂N₂O₂
SMILES

O=C1/C(C2=CC=CC=C2N1CC#C)=C3C4=CC=CC=C4NC\3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu TT, et al. Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors. J Med Chem. 2024;67(9):7620-7634. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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