PROTAC ERK5 degrader-1
Based on 1 Customer Validation
PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia.
(Pink: ERK5 ligand (HY-176529); Blue: VHL ligand (HY-42424); Black: linker (HY-43191)).
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 2919963-24-7
- Formula: C54H67F3N10O6S
- Molecular Weight:1041.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PROTAC ERK5 degrader-1 (compound 2) (0.05-1 μM; 1-5 h) degrades ERK5 in a time- and dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Molt4 cells
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Concentration:0.05 μM, 0.25 μM, 0.1 μM, 0.5 μM, 1 μM
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Incubation Time:1 h, 2 h, 3 h, 4 h, 5 h
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Result:Degraded ERK5 in a VHL-dependent manner.
Chemical Information
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CAS No. 2919963-24-7
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Appearance Solid
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Molecular Weight 1041.23
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Formula C54H67F3N10O6S
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Color White to light yellow
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SMILES
O=C(C1=C(C=C(C=C1)OC(F)(F)F)N)N2CCC(CC2)C3=NC=NC4=C3C=CC(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (48.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9604 mL | 4.8020 mL | 9.6040 mL | 24.0101 mL |
| 5 mM | 0.1921 mL | 0.9604 mL | 1.9208 mL | 4.8020 mL | |
| 10 mM | 0.0960 mL | 0.4802 mL | 0.9604 mL | 2.4010 mL | |
| 15 mM | 0.0640 mL | 0.3201 mL | 0.6403 mL | 1.6007 mL | |
| 20 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL | 1.2005 mL | |
| 25 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9604 mL | |
| 30 mM | 0.0320 mL | 0.1601 mL | 0.3201 mL | 0.8003 mL | |
| 40 mM | 0.0240 mL | 0.1201 mL | 0.2401 mL | 0.6003 mL |
PROTAC ERK5 degrader-1 Related Classifications
HY-176528 Related Classifications
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