PROTAC ERK5 degrader-1

Name: PROTAC ERK5 degrader-1
Brand: MedChemExpress
SKU: HY-176528
Rating: 4.5 (1 reviews)

Cat. No.: HY-176528 Purity: 99.58%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia.
(Pink: ERK5 ligand (HY-176529); Blue: VHL ligand (HY-42424); Black: linker (HY-43191)).

For research use only. We do not sell to patients.

PROTAC ERK5 degrader-1 Chemical Structure

CAS No. : 2919963-24-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia^[1]. (Pink: ERK5 ligand (HY-176529); Blue: VHL ligand (HY-42424); Black: linker (HY-43191)).

In Vitro

PROTAC ERK5 degrader-1 (compound 2) (0.05-1 μM; 1-5 h) degrades ERK5 in a time- and dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Molt4 cells
Concentration:	0.05 μM, 0.25 μM, 0.1 μM, 0.5 μM, 1 μM
Incubation Time:	1 h, 2 h, 3 h, 4 h, 5 h
Result:	Degraded ERK5 in a VHL-dependent manner.

Molecular Weight

1041.23

Formula

C₅₄H₆₇F₃N₁₀O₆S

CAS No.

2919963-24-7

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C(C=C(C=C1)OC(F)(F)F)N)N2CCC(CC2)C3=NC=NC4=C3C=CC(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (48.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9604 mL	4.8020 mL	9.6040 mL
5 mM	0.1921 mL	0.9604 mL	1.9208 mL
10 mM	0.0960 mL	0.4802 mL	0.9604 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) HNMR (309 KB) LCMS (336 KB)

Handling Instructions (2659 KB)

References

[1]. Inchul YOU, et al. Erk5 degraders and uses thereof. WO2023044482A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9604 mL	4.8020 mL	9.6040 mL	24.0101 mL
	5 mM	0.1921 mL	0.9604 mL	1.9208 mL	4.8020 mL
	10 mM	0.0960 mL	0.4802 mL	0.9604 mL	2.4010 mL
	15 mM	0.0640 mL	0.3201 mL	0.6403 mL	1.6007 mL
	20 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2005 mL
	25 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9604 mL
	30 mM	0.0320 mL	0.1601 mL	0.3201 mL	0.8003 mL
	40 mM	0.0240 mL	0.1201 mL	0.2401 mL	0.6003 mL