2919963-24-7
2919963-24-7
Chemical Structure
PROTAC ERK5 degrader-1
- CAS 番号: 2919963-24-7
- Formula:C54H67F3N10O6S
- Molecular Weight:1041.23
InChIKey: BOXPLNRWIHHHBO-CHCOZFFLSA-N
SMILES: O=C(C1=C(C=C(C=C1)OC(F)(F)F)N)N2CCC(CC2)C3=NC=NC4=C3C=CC(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C4
Biological Activity: PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia[1].
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PROTAC ERK5 degrader-1 | 99.58% | PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia. | ||||||||||||||||||||
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