1. PROTAC
  2. Target Protein Ligand-Linker Conjugate
  3. ERRα Ligand-Linker Conjugates 1

ERRα Ligand-Linker Conjugates 1 

Cat. No.: HY-130499 Purity: 96.70%
Handling Instructions

ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERRα degrader.

For research use only. We do not sell to patients.

ERRα Ligand-Linker Conjugates 1 Chemical Structure

ERRα Ligand-Linker Conjugates 1 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1297 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERRα degrader[1].

Molecular Weight

601.42

Formula

C₂₄H₂₀F₉N₃O₅

SMILES

NCCNC(/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=C(C(F)(F)F)C=C(C(F)(F)F)C=C2)=O.O=C(C(F)(F)F)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (332.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6627 mL 8.3137 mL 16.6273 mL
5 mM 0.3325 mL 1.6627 mL 3.3255 mL
10 mM 0.1663 mL 0.8314 mL 1.6627 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (8.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (8.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ERRα Ligand-Linker Conjugates 1Target Protein Ligand-Linker ConjugateERRαPROTACdegraderE3ligasesInhibitorinhibitorinhibit

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Product name:
ERRα Ligand-Linker Conjugates 1
Cat. No.:
HY-130499
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