BRD9 Degrader-1
BRD9 Degrader-1 is a selective BRD9 PROTAC degrader with a DC50 of 108 nM. BRD9 Degrader-1 induces the formation of a ternary complex between BRD9 and VHL, with an EC50 of 17 nM, and shows no hook effect at high concentrations. BRD9 Degrader-1 can be used for the research of synovial sarcoma.
(Pink: BRD9 ligand (HY-168695); Blue: VHL ligand (HY-125905); Black: linker).
For research use only. We do not sell to patients.
- Formula: C49H65FN12O7S2
- Molecular Weight:1017.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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BRD9 108 nM (DC50) |
VHL |
BRD9 Degrader-1 (Compound 13-7) (0-30 μM; 2 h) synergistically induces the formation of a ternary complex of BRD9 and VHL in HEK293T cells, with an EC50 of 17 nM, a maximum response rate of 1452%, and no hook effect even at concentrations as high as 30 μM[1].
BRD9 Degrader-1 (10 μM; 24 h) induces proteasome-dependent degradation of BRD9-eGFP in HEK293T cells[1].
BRD9 Degrader-1 (0-30 μM; 24 h) induces dose-dependent degradation of BRD9-eGFP in HEK293T cells, with no hook effect observed at the highest concentration of 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells expressing BRD9-eGFP
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Concentration:0, 0.12, 0.37, 1.11, 3.33, 10 and 30 μM
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Incubation Time:24 h
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Result:Induced dose-dependent degradation of BRD9-eGFP.
Showed no hook effect observed at concentrations up to 30 μM.
Maintained consistent β-actin levels across all treatments.
Chemical Information
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Molecular Weight 1017.25
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Formula C49H65FN12O7S2
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SMILES
[H][C@]1([C@@H](CCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C5(CC5)F)=O)=O)C[C@@H](C4)O)=O)[C@]1([H])C6)CN6C7=NC(N(C(C)C)CCNC(C)=O)=NC(N8CC(C8)OC9=NC=CS9)=N7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD9 Degrader-1 Related Classifications
HY-156401 Related Classifications
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