PROTAC SMARCA2/4 degrader-11
PROTAC SMARCA2/4 degrader-11 is a PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-11 induces protein ubiquitination and subsequent proteasome-mediated degradation. PROTAC SMARCA2/4-degrader-11 can be used in cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159542); Blue: Cereblon ligand (HY-163927); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2568276-71-9
- Formula: C37H41N9O4
- Molecular Weight:675.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-11 (I-321) (24 h) potently degrades SMARCA2 protein in A549 cells, with a DC50 of less than 100 nM and a degradation rate exceeding 90% after 24 hours[1].
PROTAC SMARCA2/4 degrader-11 (24 h) potently degrades SMARCA2 and SMARCA4 proteins in MV4-11 cells, with a DC50 of less than 100 nM, and the degradation rate of both proteins exceeds 90% after 24 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568276-71-9
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Molecular Weight 675.78
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Formula C37H41N9O4
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SMILES
CN1C(N(C2=C1C(C3CCC(CC3)N4CCC(CC4)N5C=C(C=N5)C6=CC(C7=CC=CC=C7O)=NN=C6N)=CC=C2)C8CCC(NC8=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-11 Related Classifications
HY-163864 Related Classifications
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