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Cat. No.: HY-182973

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SAMHD1 ligand-1

SAMHD1 ligand-1 is a SAMHD1 ligand that can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970).

For research use only. We do not sell to patients.

Formula: C₂₇H₃₂ClN₇O₃
Molecular Weight:538.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SAMHD1 ligand-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SAMHD1 ligand-1 is a SAMHD1 ligand that can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970)^[1].

IC₅₀ & Target

SAMHD1

All HIV Isoforms :

Chemical Information

Molecular Weight 538.04
Formula C₂₇H₃₂ClN₇O₃
SMILES

OCCCCN(N=C1)C(N=C2NC(CC3)CCN3CC(C=C4)=CC(Cl)=C4OC5=CC(N)=CC=C5)=C1C(N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis. J Med Chem. Published online April 3, 2026. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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