(E)-JP-2-196 TFA
Based on 1 Customer Validation
JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders.
For research use only. We do not sell to patients.
- Purity: 97.89%
- CAS No.: 3065021-33-9
- Formula: C17H19F3N2O5
- Molecular Weight:388.34
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Chemical Information
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CAS No. 3065021-33-9
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Appearance Solid
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Molecular Weight 388.34
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Formula C17H19F3N2O5
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Color Light yellow to yellow
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SMILES
OC(C(F)(F)F)=O.O=C(N1CCNCC1)/C=C/C(C2=CC=C(C=C2)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (257.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5751 mL | 12.8753 mL | 25.7506 mL | 64.3766 mL |
| 5 mM | 0.5150 mL | 2.5751 mL | 5.1501 mL | 12.8753 mL | |
| 10 mM | 0.2575 mL | 1.2875 mL | 2.5751 mL | 6.4377 mL | |
| 15 mM | 0.1717 mL | 0.8584 mL | 1.7167 mL | 4.2918 mL | |
| 20 mM | 0.1288 mL | 0.6438 mL | 1.2875 mL | 3.2188 mL | |
| 25 mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.5751 mL | |
| 30 mM | 0.0858 mL | 0.4292 mL | 0.8584 mL | 2.1459 mL | |
| 40 mM | 0.0644 mL | 0.3219 mL | 0.6438 mL | 1.6094 mL | |
| 50 mM | 0.0515 mL | 0.2575 mL | 0.5150 mL | 1.2875 mL | |
| 60 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0729 mL | |
| 80 mM | 0.0322 mL | 0.1609 mL | 0.3219 mL | 0.8047 mL | |
| 100 mM | 0.0258 mL | 0.1288 mL | 0.2575 mL | 0.6438 mL |
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