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Cat. No.: HY-W854844

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JP-2-196

JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia).

For research use only. We do not sell to patients.

CAS No.: 2913587-30-9
Formula: C₁₅H₁₈N₂O₃
Molecular Weight:274.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JP-2-196 Chemical Structure

CAS No.: 2913587-30-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

All Epigenetic Reader Domain Isoforms :

In Vitro

JP-2-196 (0.1-50 μM) covalently binds recombinant RNF126 protein in a dose-dependent manner^[1].
JP-2-196 (50 μM) competes with the JP-2-196-alkyne probe for the same binding site on recombinant RNF126^[1].
JP-2-196 specifically binds to the zinc-binding site of RNF126 (1-40) or its vicinity, without altering the folding or stability of the protein^[1].
JP-2-196 (24 h) alone does not induce degradation of either the long or short isoform of BRD4 in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2913587-30-9
Molecular Weight 274.32
Formula C₁₅H₁₈N₂O₃
SMILES

O=C(C=CC(=O)N1CCNCC1)C2=CC=C(OC)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS central science. 2023 May 24;9(5):915-926. [Content Brief]

[2]. Fu MJ, et al. Unleashing the Power of Covalent Drugs for Protein Degradation. Medicinal research reviews. 2025 Jul;45(4):1045-1076. [Content Brief]

[3]. Chang HR, et al. RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy. Biomedicines. 2023 Sep 13;11(9):2527. [Content Brief]

[4]. Palaferri L, et al. Recent Advances in CBP/EP300 Degraders. Chimia. 2025 Mar 26;79(3):137-145.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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