JP-2-196 hydrochloride
JP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C15H19ClN2O3
- Masse moléculaire:310.78
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
BRD4 |
In Vitro
JP-2-196 (0.1-50 μM) hydrochloride covalently binds recombinant RNF126 protein in a dose-dependent manner[1].
JP-2-196 (50 μM) hydrochloride competes with the JP-2-196 hydrochloride-alkyne probe for the same binding site on recombinant RNF126[1].
JP-2-196 hydrochloride specifically binds to the zinc-binding site of RNF126 (1-40) or its vicinity, without altering the folding or stability of the protein[1].
JP-2-196 (24 h) hydrochloride alone does not induce degradation of either the long or short isoform of BRD4 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
Masse moléculaire 310.78
-
Formule C15H19ClN2O3
-
SMILES
O=C(C1=CC=C(OC)C=C1)/C=C/C(N2CCNCC2)=O.Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS central science. 2023 May 24;9(5):915-926. [Content Brief]
[2]. Fu MJ, et al. Unleashing the Power of Covalent Drugs for Protein Degradation. Medicinal research reviews. 2025 Jul;45(4):1045-1076. [Content Brief]
[3]. Chang HR, et al. RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy. Biomedicines. 2023 Sep 13;11(9):2527. [Content Brief]
[4]. Palaferri L, et al. Recent Advances in CBP/EP300 Degraders. Chimia. 2025 Mar 26;79(3):137-145.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JP-2-196 hydrochloride Related Classifications
HY-W854844B Related Classifications
Powered by Bioz