2913587-30-9
Chemical Structure
JP-2-196
- CAS No.: 2913587-30-9
- Formula:C15H18N2O3
- Molecular Weight:274.32
IUPAC Name: (E)-1-(4-methoxyphenyl)-4-(piperazin-1-yl)but-2-ene-1,4-dione
InChIKey: WEAHZKJGXWQOFV-VOTSOKGWSA-N
SMILES: O=C(C=CC(=O)N1CCNCC1)C2=CC=C(OC)C=C2
Biological Activity: JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia)[1][2][3][4].
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JP-2-196 | JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia). | |||||||||||||||||||||
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References
- [1]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS central science. 2023 May 24;9(5):915-926. [Content Brief]
- [2]. Fu MJ, et al. Unleashing the Power of Covalent Drugs for Protein Degradation. Medicinal research reviews. 2025 Jul;45(4):1045-1076. [Content Brief]
- [3]. Chang HR, et al. RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy. Biomedicines. 2023 Sep 13;11(9):2527. [Content Brief]
- [4]. Palaferri L, et al. Recent Advances in CBP/EP300 Degraders. Chimia. 2025 Mar 26;79(3):137-145.
