PROTAC USP39 Degrader-1

Cat. No.: HY-180907 Purity: 98.61%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC USP39 Degrader-1 (compound USP39_PROTAC_V1) is a potent and selective PROTAC USP39 degrader. PROTAC USP39 Degrader-1 induces degradation of USP39 by recruiting the VHL E3 ligase via a hydroxyl-proline-containing ligand, forming a ternary complex with a K_d of 232 nM. PROTAC USP39 Degrader-1 degrades USP39 in a VHL-, proteasome-, and the neddylation pathway-dependent manner.
(Pink: Oct3/4 ligand (HY-18772); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-140468)).

For research use only. We do not sell to patients.

PROTAC USP39 Degrader-1 Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC USP39 Degrader-1 (compound USP39_PROTAC_V1) is a potent and selective PROTAC USP39 degrader. PROTAC USP39 Degrader-1 induces degradation of USP39 by recruiting the VHL E3 ligase via a hydroxyl-proline-containing ligand, forming a ternary complex with a K_d of 232 nM. PROTAC USP39 Degrader-1 degrades USP39 in a VHL-, proteasome-, and the neddylation pathway-dependent manner^[1]. (Pink: Oct3/4 ligand (HY-18772); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-140468)).

Molecular Weight

870.48

Formula

C₄₁H₅₂ClN₇O₈S₂

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCCOCCNC(C1=CSC(NC2=CC=C(C=C2)Cl)=N1)=O)N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (114.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1488 mL	5.7440 mL	11.4879 mL
5 mM	0.2298 mL	1.1488 mL	2.2976 mL
10 mM	0.1149 mL	0.5744 mL	1.1488 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.61%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (247 KB) HNMR (104 KB) RP-HPLC (132 KB) LCMS (195 KB)

Handling Instructions (2659 KB)

References

[1]. Schäfer D, et al. Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. Angew Chem Int Ed Engl. 2025 Dec 21:e16809. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1488 mL	5.7440 mL	11.4879 mL	28.7198 mL
	5 mM	0.2298 mL	1.1488 mL	2.2976 mL	5.7440 mL
	10 mM	0.1149 mL	0.5744 mL	1.1488 mL	2.8720 mL
	15 mM	0.0766 mL	0.3829 mL	0.7659 mL	1.9147 mL
	20 mM	0.0574 mL	0.2872 mL	0.5744 mL	1.4360 mL
	25 mM	0.0460 mL	0.2298 mL	0.4595 mL	1.1488 mL
	30 mM	0.0383 mL	0.1915 mL	0.3829 mL	0.9573 mL
	40 mM	0.0287 mL	0.1436 mL	0.2872 mL	0.7180 mL
	50 mM	0.0230 mL	0.1149 mL	0.2298 mL	0.5744 mL
	60 mM	0.0191 mL	0.0957 mL	0.1915 mL	0.4787 mL
	80 mM	0.0144 mL	0.0718 mL	0.1436 mL	0.3590 mL
	100 mM	0.0115 mL	0.0574 mL	0.1149 mL	0.2872 mL