PROTAC USP39 Degrader-1
Based on 1 Customer Validation
PROTAC USP39 Degrader-1 (compound USP39_PROTAC_V1) is a potent and selective PROTAC USP39 degrader. PROTAC USP39 Degrader-1 induces degradation of USP39 by recruiting the VHL E3 ligase via a hydroxyl-proline-containing ligand, forming a ternary complex with a Kd of 232 nM. PROTAC USP39 Degrader-1 degrades USP39 in a VHL-, proteasome-, and the neddylation pathway-dependent manner.
(Pink: USP39 ligand (HY-18772); Blue: VHL ligand (HY-125845); Black: linker (HY-140468)).
For research use only. We do not sell to patients.
- Purity: 98.61%
- Formula: C41H52ClN7O8S2
- Molecular Weight:870.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 870.48
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Formula C41H52ClN7O8S2
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Color White to off-white
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SMILES
O=C(CCOCCOCCOCCNC(C1=CSC(NC2=CC=C(C=C2)Cl)=N1)=O)N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (114.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1488 mL | 5.7440 mL | 11.4879 mL | 28.7198 mL |
| 5 mM | 0.2298 mL | 1.1488 mL | 2.2976 mL | 5.7440 mL | |
| 10 mM | 0.1149 mL | 0.5744 mL | 1.1488 mL | 2.8720 mL | |
| 15 mM | 0.0766 mL | 0.3829 mL | 0.7659 mL | 1.9147 mL | |
| 20 mM | 0.0574 mL | 0.2872 mL | 0.5744 mL | 1.4360 mL | |
| 25 mM | 0.0460 mL | 0.2298 mL | 0.4595 mL | 1.1488 mL | |
| 30 mM | 0.0383 mL | 0.1915 mL | 0.3829 mL | 0.9573 mL | |
| 40 mM | 0.0287 mL | 0.1436 mL | 0.2872 mL | 0.7180 mL | |
| 50 mM | 0.0230 mL | 0.1149 mL | 0.2298 mL | 0.5744 mL | |
| 60 mM | 0.0191 mL | 0.0957 mL | 0.1915 mL | 0.4787 mL | |
| 80 mM | 0.0144 mL | 0.0718 mL | 0.1436 mL | 0.3590 mL | |
| 100 mM | 0.0115 mL | 0.0574 mL | 0.1149 mL | 0.2872 mL |
PROTAC USP39 Degrader-1 Related Classifications
HY-180907 Related Classifications
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