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Cat. No.: HY-182086

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Copanlisib-NH

Copanlisib-NH is a PI3Kα/δ ligand. Copanlisib-NH can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC PI3Kα/δ, such as PROTAC PI3Kα/δ degrader-1 (HY-182083). Copanlisib-NH can be used in breast cancer research.

For research use only. We do not sell to patients.

CAS No.: 2355277-02-8
Formula: C₂₃H₂₉N₉O₃
Molecular Weight:479.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Copanlisib-NH Chemical Structure

CAS No.: 2355277-02-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Targetsup>[1]

PI3Kα

PI3Kδ

All PI3K Isoforms :

Chemical Information

CAS No. 2355277-02-8
Molecular Weight 479.53
Formula C₂₃H₂₉N₉O₃
SMILES

NC(N=C1)=NC=C1C(NC(N2C3=NCC2)=NC4=C3C=CC(OCCCN5CCNCC5)=C4OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hou Y, et al. Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability. J Med Chem. Published online March 8, 2026. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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