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Cat. No.: HY-182086

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Copanlisib-NH

Copanlisib-NH is a PI3Kα/δ ligand. Copanlisib-NH can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC PI3Kα/δ, such as PROTAC PI3Kα/δ degrader-1 (HY-182083). Copanlisib-NH can be used in breast cancer research.

For research use only. We do not sell to patients.

CAS No.: 2355277-02-8
Formula: C₂₃H₂₉N₉O₃
Molecular Weight:479.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Copanlisib-NH Chemical Structure

CAS No.: 2355277-02-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

sup>[1]

PI3Kα

PI3Kδ

All PI3K Isoforms :

Chemical Information

CAS No. 2355277-02-8
Molecular Weight 479.53
Formula C₂₃H₂₉N₉O₃
SMILES

NC(N=C1)=NC=C1C(NC(N2C3=NCC2)=NC4=C3C=CC(OCCCN5CCNCC5)=C4OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hou Y, et al. Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability. J Med Chem. Published online March 8, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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Copanlisib-NH

All PI3K Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

Copanlisib-NH Related Classifications

HY-182086 Related Classifications

Bioz

Keywords

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