PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively.
(Pink: Bcl-xL ligand (HY-44432); Blue: IAP ligand (HY-184595); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2450351-07-0
- Formula: C76H96ClF3N10O11S3
- Molecular Weight:1514.28
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
cIAP1 |
Bcl-xL |
PROTAC Bcl-xL degrader-1 (Compound 8a; 0.01-3 μM; 16 hours; MyLa 1929 cells) treatment potently and dose-dependently induces BCL-XL degradation in MyLa 1929 cells[1].
PROTAC Bcl-xL degrader-1 (Compound 8a) is able to induce remarkable BCL-XL degradation in a dose-dependent manner across all tested cell lines (A549, MDA-MB-231, SW620, MeWo, SK-MEL28, and CHL-1 cell lines), suggesting the broad application across cancer types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MyLa 1929 cells
-
Concentration:0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM
-
Incubation Time:16 hours
-
Result:Potently and dose-dependently induced BCL-XL degradation in MyLa 1929 cells.
Chemical Information
-
CAS No. 2450351-07-0
-
Molecular Weight 1514.28
-
Formula C76H96ClF3N10O11S3
-
SMILES
ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[C@H](NC([C@@H]9C(C)(C[C@@]([H])(N9C%10=O)OCC[C@@H]%10NC([C@@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC Bcl-xL degrader-1 Related Classifications
HY-131188 Related Classifications
Powered by Bioz