1. PROTAC
    Apoptosis
  2. PROTAC
    Bcl-2 Family
  3. PROTAC Bcl-xL degrader-1

PROTAC Bcl-xL degrader-1 

Cat. No.: HY-131188
Handling Instructions

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively.

For research use only. We do not sell to patients.

PROTAC Bcl-xL degrader-1 Chemical Structure

PROTAC Bcl-xL degrader-1 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All PROTAC Isoform Specific Products:

View All Bcl-2 Family Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively[1].

IC50 & Target[1]

cIAP1

 

Bcl-xL

 

In Vitro

PROTAC Bcl-xL degrader-1 (Compound 8a; 0.01-3 μM; 16 hours; MyLa 1929 cells) treatment potently and dose-dependently induces BCL-XL degradation in MyLa 1929 cells[1].
PROTAC Bcl-xL degrader-1 (Compound 8a) is able to induce remarkable BCL-XL degradation in a dose-dependent manner across all tested cell lines (A549, MDA-MB-231, SW620, MeWo, SK-MEL28, and CHL-1 cell lines), suggesting the broad application across cancer types[1].

Western Blot Analysis[1]

Cell Line: MyLa 1929 cells
Concentration: 0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM
Incubation Time: 16 hours
Result: Potently and dose-dependently induced BCL-XL degradation in MyLa 1929 cells.
Molecular Weight

1514.28

Formula

C₇₆H₉₆ClF₃N₁₀O₁₁S₃

SMILES

ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[[email protected]](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[[email protected]](NC([[email protected]@H]9C(C)(C[[email protected]@]([H])(N9C%10=O)OCC[[email protected]@H]%10NC([[email protected]@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC Bcl-xL degrader-1PROTACBcl-2 FamilyProteolysis-targeting chimeraBcl-xLIAPdegradertoxicityantitumorplateletsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
PROTAC Bcl-xL degrader-1
Cat. No.:
HY-131188
Quantity:
MCE Japan Authorized Agent: