1. PROTAC Apoptosis
  2. PROTACs Bcl-2 Family
  3. PROTAC Bcl-xL degrader-1

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively.

For research use only. We do not sell to patients.

PROTAC Bcl-xL degrader-1 Chemical Structure

PROTAC Bcl-xL degrader-1 Chemical Structure

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Description

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively[1].

IC50 & Target[1]

cIAP1

 

Bcl-xL

 

In Vitro

PROTAC Bcl-xL degrader-1 (Compound 8a; 0.01-3 μM; 16 hours; MyLa 1929 cells) treatment potently and dose-dependently induces BCL-XL degradation in MyLa 1929 cells[1].
PROTAC Bcl-xL degrader-1 (Compound 8a) is able to induce remarkable BCL-XL degradation in a dose-dependent manner across all tested cell lines (A549, MDA-MB-231, SW620, MeWo, SK-MEL28, and CHL-1 cell lines), suggesting the broad application across cancer types[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MyLa 1929 cells
Concentration: 0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM
Incubation Time: 16 hours
Result: Potently and dose-dependently induced BCL-XL degradation in MyLa 1929 cells.
Molecular Weight

1514.28

Formula

C76H96ClF3N10O11S3

SMILES

ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[C@H](NC([C@@H]9C(C)(C[C@@]([H])(N9C%10=O)OCC[C@@H]%10NC([C@@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PROTAC Bcl-xL degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC Bcl-xL degrader-1
Cat. No.:
HY-131188
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