1. Apoptosis
    PROTAC
  2. Bcl-2 Family
    Ligand for Target Protein for PROTAC
  3. Navitoclax-piperazine

Navitoclax-piperazine (Synonyms: ABT-263-piperazine)

Cat. No.: HY-44432
Handling Instructions

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604).

For research use only. We do not sell to patients.

Navitoclax-piperazine Chemical Structure

Navitoclax-piperazine Chemical Structure

CAS No. : 2143096-93-7

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

IC50 & Target

Bcl-xL

 

Molecular Weight

973.63

Formula

C₄₇H₅₆ClF₃N₆O₅S₃

CAS No.

2143096-93-7

SMILES

O=C(NS(=O)(C1=CC=C(N[[email protected]@H](CSC2=CC=CC=C2)CCN3CCNCC3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Navitoclax-piperazineABT-263-piperazineBcl-2 FamilyLigand for Target Protein for PROTACTarget Protein-binding MoietyB-celllymphomaVHLE3ubiquitinligaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Navitoclax-piperazine
Cat. No.:
HY-44432
Quantity:
MCE Japan Authorized Agent: