1. Apoptosis
    PROTAC
  2. Bcl-2 Family
    Ligand for Target Protein for PROTAC
  3. Navitoclax-piperazine

Navitoclax-piperazine (Synonyms: ABT-263-piperazine)

Cat. No.: HY-44432 Purity: 98.83%
Handling Instructions

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604).

For research use only. We do not sell to patients.

Navitoclax-piperazine Chemical Structure

Navitoclax-piperazine Chemical Structure

CAS No. : 2143096-93-7

Size Price Stock Quantity
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

IC50 & Target[1]

Bcl-xL

 

Molecular Weight

973.63

Formula

C₄₇H₅₆ClF₃N₆O₅S₃

CAS No.

2143096-93-7

SMILES

O=C(NS(=O)(C1=CC=C(N[[email protected]@H](CSC2=CC=CC=C2)CCN3CCNCC3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (256.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0271 mL 5.1354 mL 10.2708 mL
5 mM 0.2054 mL 1.0271 mL 2.0542 mL
10 mM 0.1027 mL 0.5135 mL 1.0271 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Navitoclax-piperazineABT-263-piperazineBcl-2 FamilyLigand for Target Protein for PROTACTarget Protein-binding MoietyB-celllymphomaVHLE3ubiquitinligaseInhibitorinhibitorinhibit

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Product Name:
Navitoclax-piperazine
Cat. No.:
HY-44432
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