1. Apoptosis
  2. Bcl-2 Family
  3. BI-3802

BI-3802 

Cat. No.: HY-108705 Purity: 99.43%
Handling Instructions

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity.

For research use only. We do not sell to patients.

BI-3802 Chemical Structure

BI-3802 Chemical Structure

CAS No. : 2166387-65-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 396 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2640 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2].

IC50 & Target

IC50: ≤ 3 nM (BCL6 BTB)[1]

In Vitro

BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1].
BI-3802 increases the interaction between BCL6 and SIAH1 (EC50 = 64 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

484.98

Formula

C24H29ClN6O3

CAS No.
SMILES

ClC1=CN=C(N2C[[email protected]](C)C[[email protected]](C)C2)N=C1NC3=CC(C=C(OCC(NC)=O)C(N4C)=O)=C4C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0619 mL 10.3097 mL 20.6194 mL
5 mM 0.4124 mL 2.0619 mL 4.1239 mL
10 mM 0.2062 mL 1.0310 mL 2.0619 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Product Name:
BI-3802
Cat. No.:
HY-108705
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