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Cat. No.: HY-180798

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BCR-ABL degrader 1

BCR-ABL degrader 1 (Compound 23) is a HyT-based BCR-ABL degrader with a DC₅₀ of 19.9 μM. BCR-ABL degrader 1 can be used in the research of chronic myeloid leukemia.

For research use only. We do not sell to patients.

Formula: C₃₃H₃₆F₃N₇O₆
Molecular Weight:683.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BCR-ABL degrader 1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

BCR-ABL degrader 1 (Compound 23) is a HyT-based BCR-ABL degrader with a DC₅₀ of 19.9 μM. BCR-ABL degrader 1 can be used in the research of chronic myeloid leukemia^[1].

IC₅₀ & Target

DC₅₀: 19.9 μM (BCR-ABL)^[1]

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Chemical Information

Molecular Weight 683.68
Formula C₃₃H₃₆F₃N₇O₆
SMILES

O=C(N1C(C[C@H](NC(OC(C)(C)C)=O)C(NC2=CC=CC(C3=NC=NC(NC4=CC=C(OC(F)(F)F)C=C4)=C3)=C2)=O)=CN=C1)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun H, et al. Identification of N-tert-butyloxycarbonyl protected amino acids as novel hydrophobic tags to induce targeted protein degradation. Eur J Med Chem. 2026 Feb 5;303:118493. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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