2. PROTAC Anti-infection
  3. PROTACs SARS-CoV
  4. PROTAC SARS-CoV-2 Mpro degrader-1

PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity.

For research use only. We do not sell to patients.

PROTAC SARS-CoV-2 Mpro degrader-1

PROTAC SARS-CoV-2 Mpro degrader-1 Chemical Structure

CAS No. : 3029579-46-9

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PROTAC SARS-CoV-2 Mpro degrader-1 Related Antibodies

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Description

PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity[1].

IC50 & Target

SARS-CoV[1]
Cellular Effect
Cell Line Type Value Description References
MRC5 CC50
238 μM
Compound: 5
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34534839]
MRC5 CC50
238 μM
Compound: 5
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38394929]
Vero CC50
> 250 μM
Compound: 5
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38394929]
Vero C1008 CC50
> 250 μM
Compound: 5
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
[PMID: 34534839]
Molecular Weight

995.62

Formula

C52H63ClN8O8S
CAS No.
SMILES

ClC1=CC=C(C(N2C3=CC=C(OC)C=C3C(CC(NCCN4CCN(CC4)C(CCC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)C(C)(C)C)=O)=O)=O)=C2C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC SARS-CoV-2 Mpro degrader-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SARS-CoV-2 Mpro degrader-13029579-46-9PROTACsSARS-CoVSARS coronavirusSARS-CoV-2proteaseInhibitorinhibitorinhibit

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