3029579-46-9
Chemical Structure
PROTAC SARS-CoV-2 Mpro degrader-1
- CAS No.: 3029579-46-9
- Formula:C52H63ClN8O8S
- Molecular Weight:995.62
InChIKey: JLWIAWADGYKUSP-NTIUMALKSA-N
SMILES: ClC1=CC=C(C(N2C3=CC=C(OC)C=C3C(CC(NCCN4CCN(CC4)C(CCC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)C(C)(C)C)=O)=O)=O)=C2C)=O)C=C1
Biological Activity: PROTAC SARS-CoV-2 Mpro degrader-1 is a SARS-CoV-2 Mpro PROTAC degrader with a DC50 of 18.1 μM. PROTAC SARS-CoV-2 Mpro degrader-1 recruits the Von-Hippel Lindau (VHL) E3 ligase to mediate ubiquitination and proteasomal degradation of SARS-CoV-2 Mpro, without inhibiting the catalytic activity of Mpro. PROTAC SARS-CoV-2 Mpro degrader-1 exhibits broad-spectrum antiviral activity against coronaviruses (SARS-CoV-2, HCoV-OC43, HCoV-229E). PROTAC SARS-CoV-2 Mpro degrader-1 can be used in studies related to SARS-CoV-2 infection, HCoV-OC43 infection, and HCoV-229E infection[1].
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PROTAC SARS-CoV-2 Mpro degrader-1 | PROTAC SARS-CoV-2 Mpro degrader-1 is a SARS-CoV-2 Mpro PROTAC degrader with a DC50 of 18.1 μM. PROTAC SARS-CoV-2 Mpro degrader-1 recruits the Von-Hippel Lindau (VHL) E3 ligase to mediate ubiquitination and proteasomal degradation of SARS-CoV-2 Mpro, without inhibiting the catalytic activity of Mpro. PROTAC SARS-CoV-2 Mpro degrader-1 exhibits broad-spectrum antiviral activity against coronaviruses (SARS-CoV-2, HCoV-OC43, HCoV-229E). PROTAC SARS-CoV-2 Mpro degrader-1 can be used in studies related to SARS-CoV-2 infection, HCoV-OC43 infection, and HCoV-229E infection. | |||||||||||||||||||||
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